NFLymSI-18 是一项患者报告的结果指标，包括最高优先级的症状、情绪问题、治疗副作用以及淋巴瘤患者和肿瘤学家确定的其他问题。本研究评估了 NFLymSI-18 对于惰性 B 细胞非霍奇金淋巴瘤 (iNHL) 患者的内容有效性，重点是疾病相关症状体格 (DRS-P) 子量表。确诊 iNHL 的患者在诊所就诊期间接受过一种或多种治疗的患者被招募。患者在半结构化访谈中描述了与 iNHL 相关的症状、治疗副作用和情绪担忧。使用NVivo10分析定性数据。第18次访谈获得数据饱和度。大多数参与者（67%）患有滤泡性淋巴瘤。 28% 的参与者患有边缘区淋巴瘤，一名参与者患有淋巴浆细胞样淋巴瘤/华氏巨球蛋白血症。 18 名参与者的平均年龄为 67 岁。 56%的样本是男性。大多数参与者（67%）拥有大学或高级学位。当被要求描述他们的 iNHL 症状时，患者最常讨论的是肿胀 (n = 14)、疲劳 (n = 11) 和疼痛 (n = 8)。三名患者分别提到了以下症状：焦虑、食欲不振、皮疹、睡眠中断、呼吸困难和不适。 NFLymSI-18 内容与这些问题的映射显示该工具包括所有最常提到的症状。这项研究支持 NFLymSI-18（包括其 DRS-P 子量表）对于 iNHL 患者的内容有效性。该仪器对肿胀、疲劳和疼痛等最常见的症状显示出很强的有效性。患者报告的其他症状的多样性与 iNHL 的异质症状一致。© 2024。作者。

The NFLymSI-18 is a patient-reported outcome measure comprised of the highest priority symptoms, emotional concerns, treatment side effects, and other concerns identified by lymphoma patients and oncologists. This study assessed the content validity of the NFLymSI-18 for patients with indolent B-cell non-Hodgkin's lymphoma (iNHL), with a focus on the Disease-Related Symptoms Physical (DRS-P) subscale.Patients with a confirmed iNHL diagnosis who had received one or more lines of treatment were recruited during clinic visits. Patients described their symptoms, treatment side effects, and emotional concerns related to iNHL in a semi-structured interview. Qualitative data were analyzed using NVivo10.Data saturation was obtained by the 18th interview. Most participants (67%) had follicular lymphoma. 28% of participants had marginal zone lymphoma, and one participant had lymphoplasmacytoid lymphoma/Waldenström macroglobulinemia. Mean age of the 18 participants was 67 years. 56% of the sample was male. Most participants (67%) had a college or advanced degree. When asked to describe their iNHL symptoms, patients most often discussed swelling (n = 14), fatigue (n = 11), and pain (n = 8). The following symptoms were mentioned by three patients each: anxiety, appetite loss, rash, sleep disruption, trouble breathing, and malaise. Mapping of NFLymSI-18 content to these concerns showed the instrument includes all those most frequently mentioned symptoms.This study supports the content validity of the NFLymSI-18, including its DRS-P Subscale, for patients with iNHL. The instrument shows strong validity for the most referenced symptoms of swelling, fatigue, and pain. The diversity of additional symptoms reported by patients is consistent with the heterogeneous symptomology of iNHL.© 2024. The Author(s).