自 20 世纪 90 年代初以来，Robert 和 Szabo 的细胞保护概念已有十多年历史，但仍未在治疗中实施，我们建议稳定的胃十五肽 BPC 157 作为细胞保护概念最相关的介质。因此，它可以将胃和胃肠道粘膜维护、上皮和内皮细胞保护转化为其他组织愈合（器官保护）的治疗，易于应用，在人胃液中天然且稳定超过 24 小时。这些压倒了当前的临床证据（即溃疡性结肠炎，II 期，无副作用，毒理学研究中无致死剂量 (LD1)），因为 BPC 157 疗法有效地结合了各种组织愈合和病变对抗。 BPC 157 细胞保护相关性和血管恢复、侧支通路激活、膜稳定剂、眼部治疗、伤口愈合能力、脑-肠和肠-脑功能、肿瘤恶病质对抗、肌肉、肌腱、韧带和骨骼紊乱对抗以及心脏最近的评论中出现了心律失常、心肌梗塞、心力衰竭、肺动脉高压、心律失常和血栓形成的对抗。在这里，作为概念解析，我们回顾了晚期魏尔啸三联征情况的反作用，通过激活侧支救援途径，根据损伤，激活奇静脉直接血流输送，以抵消从酒精背景开始的闭塞/闭塞样综合征。胃部病变。主要血管衰竭（下腔静脉和肠系膜上静脉充血、奇静脉塌陷、腹主动脉塌陷）的对抗包括脑（脑内和室内出血）、心脏（充血、严重心律失常）、肺（出血）和充血以及肝、肾、胃肠道、颅内（上矢状窦）、门脉和腔静脉高压、主动脉低血压以及血栓形成、外周和中枢病变。© 2024。作者获得 Springer Nature Switzerland 的独家许可股份公司。

Since the early 1990s, when Robert's and Szabo's cytoprotection concept had already been more than one decade old, but still not implemented in therapy, we suggest the stable gastric pentadecapeptide BPC 157 as the most relevant mediator of the cytoprotection concept. Consequently, it can translate stomach and gastrointestinal mucosal maintenance, epithelium, and endothelium cell protection to the therapy of other tissue healing (organoprotection), easily applicable, as native and stable in human gastric juice for more than 24 h. These overwhelm current clinical evidence (i.e., ulcerative colitis, phase II, no side effects, and no lethal dose (LD1) in toxicology studies), as BPC 157 therapy effectively combined various tissue healing and lesions counteraction. BPC 157 cytoprotection relevance and vascular recovery, activation of collateral pathways, membrane stabilizer, eye therapy, wound healing capability, brain-gut and gut-brain functioning, tumor cachexia counteraction, muscle, tendon, ligament, and bone disturbances counteraction, and the heart disturbances, myocardial infarction, heart failure, pulmonary hypertension, arrhythmias, and thrombosis counteraction appeared in the recent reviews. Here, as concept resolution, we review the counteraction of advanced Virchow triad circumstances by activation of the collateral rescuing pathways, depending on injury, activated azygos vein direct blood flow delivery, to counteract occlusion/occlusion-like syndromes starting with the context of alcohol-stomach lesions. Counteraction of major vessel failure (congested inferior caval vein and superior mesenteric vein, collapsed azygos vein, collapsed abdominal aorta) includes counteraction of the brain (intracerebral and intraventricular hemorrhage), heart (congestion, severe arrhythmias), lung (hemorrhage), and congestion and lesions in the liver, kidney, and gastrointestinal tract, intracranial (superior sagittal sinus), portal and caval hypertension, aortal hypotension, and thrombosis, peripherally and centrally.© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.