PDGF受体通过调节参与与上皮或内皮细胞的旁分泌指导性相互作用的间充质细胞，在发育和生理过程中发挥关键作用。肿瘤生物学研究以及对患者组织样本的分析有力地表明，PDGF 信号通路在各种类型的人类癌症中也至关重要。本综述总结了实验结果和相关研究，探讨了 PDGFR 在肿瘤微环境间充质细胞中的生物学机制和临床相关性。总的来说，这些研究支持了这样的总体概念：PDGF 系统是肿瘤生长、转移和药物疗效的关键调节因子，表明尚未开发的靶向机会。间质 PDGFR 表达的患者间差异与预后和治疗反应相关，不仅表明在即将进行的治疗研究中需要分层方法，而且还意味着开发 PDGFR 作为临床实用生物标志物的潜力，有趣的是， PDGFR 定向治疗之外的设置。© 2024。作者。

PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine instructive interactions with epithelial or endothelial cells. Tumor biology studies, alongside analyses of patient tissue samples, provide strong indications that the PDGF signaling pathways are also critical in various types of human cancer. This review summarizes experimental findings and correlative studies, which have explored the biological mechanisms and clinical relevance of PDGFRs in mesenchymal cells of the tumor microenvironment. Collectively, these studies support the overall concept that the PDGF system is a critical regulator of tumor growth, metastasis, and drug efficacy, suggesting yet unexploited targeting opportunities. The inter-patient variability in stromal PDGFR expression, as being linked to prognosis and treatment responses, not only indicates the need for stratified approaches in upcoming therapeutic investigations but also implies the potential for the development of PDGFRs as biomarkers of clinical utility, interestingly also in settings outside PDGFR-directed treatments.© 2024. The Author(s).