出血性中风因其高发病率和死亡率而成为一个全球性健康问题。烟酰胺核苷是烟酰胺腺嘌呤二核苷酸的重要前体，具有高生物利用度、安全性以及对许多细胞信号传导过程的强大作用。本研究旨在探讨烟酰胺核苷对胶原酶诱导的出血性中风的保护作用及其潜在作用机制。通过将胶原酶立体定向注射到成年雄性癌症研究所小鼠的右侧纹状体中，构建脑出血模型。 30分钟后，通过尾静脉施用烟酰胺核苷。在不同时间点处死小鼠进行评估。烟酰胺核苷可减少胶原酶引起的出血面积，显着降低脑含水量和组织病理学损伤，促进神经功能恢复，抑制活性氧产生和神经炎症。烟酰胺核苷通过抑制神经炎症和氧化应激，对胶原酶诱导的脑出血发挥神经保护作用。© 2024。作者。

Hemorrhagic stroke is a global health problem owing to its high morbidity and mortality rates. Nicotinamide riboside is an important precursor of nicotinamide adenine dinucleotide characterized by a high bioavailability, safety profile, and robust effects on many cellular signaling processes. This study aimed to investigate the protective effects of nicotinamide riboside against collagenase-induced hemorrhagic stroke and its underlying mechanisms of action. An intracerebral hemorrhage model was constructed by stereotactically injecting collagenase into the right striatum of adult male Institute for Cancer Research mice. After 30 minutes, nicotinamide riboside was administered via the tail vein. The mice were sacrificed at different time points for assessments. Nicotinamide riboside reduced collagenase-induced hemorrhagic area, significantly reduced cerebral water content and histopathological damage, promoted neurological function recovery, and suppressed reactive oxygen species production and neuroinflammation. Nicotinamide riboside exerts neuroprotective effects against collagenase-induced intracerebral hemorrhage by inhibiting neuroinflammation and oxidative stress.© 2024. The Author(s).