肝病每年导致 200 万人死亡，它会导致慢性肝病 (CLD) 和肝硬化，每年导致约 100 万人死亡。肝毒性引起的肝损伤的治疗方案各不相同，包括药物治疗（N-乙酰半胱氨酸、皮质类固醇和熊去氧胆酸）、改变生活方式，有时还需要进行肝移植。然而，效果各不相同，而且一些治疗方法存在风险和副作用，这凸显了改进治疗方法的必要性。九里香 (MK) 以其保肝、抗氧化、抗炎、抗菌、肾保护、保肝、胃保护、心脏保护、神经保护、伤口愈合、抗癌和免疫调节等作用而闻名。这篇综述强调了MK 对抗重金属、药物滥用、异生素等引起的肝损伤。我们在 PubMed、Google Scholar 等多个数据库中全面搜索了有关 MK 的各种肝毒物和保肝活性的文章。研究人员应用了特定的搜索术语和限制，得出了 149 篇符合预定纳入标准的文章进行最终分析，并排除了不相关的研究。根据现有文献，MK 的植物化学成分，例如存在于各种提取物中的类黄酮、单宁和生物碱，通过改变氧化和内质网应激、重建肝脏生化标志物和酶，在逆转肝毒性作用方面发挥着至关重要的作用参与代谢，表示改善活性，并控制促炎细胞因子的表达。总之，这篇综述强调了 MK 作为天然保肝剂的巨大潜力，可针对重金属、异生物质和常见肝毒性药物引起的一系列损伤提供多功能防御。版权所有 © Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Liver disease, responsible for two million annual deaths, causes Chronic Liver Disease (CLD) and cirrhosis, causing roughly a million deaths yearly. Treatment options for liver injury induced by hepatotoxicity vary, including medication (N-acetylcysteine, corticosteroids, and ursodeoxycholic acid), lifestyle changes, and sometimes liver transplant. However, effectiveness varies, and some treatments carry risks and side effects, highlighting the need for improved therapeutic approaches. Murraya koenigii (MK) is known for its hepatoprotective, antioxidant, anti-inflammatory, anti-microbial, nephroprotective, hepatoprotective, gastroprotective, cardioprotective, neuroprotective, wound-healing, anti-cancerous and immunomodulatory effects, etc. This review highlights the effectiveness of MK against liver damage induced by heavy metals, drug abuse, xenobiotics, etc. A comprehensive search across multiple databases like PubMed, Google Scholar, and others for articles on various hepatotoxicants and hepatoprotective activity of MK was conducted. The researchers applied specific search terms and limits, resulting in 149 eligible articles for final analysis, meeting predetermined inclusion criteria and excluding irrelevant studies. According to the available literature, the phytochemical components of MK, such as flavonoids, tannins, and alkaloids present in various extracts, play a crucial role in reversing the hepatotoxic effects by modifying oxidative and ER stresses, re-establishing the hepatic biochemical markers and enzymes involved in metabolism denoting ameliorative activity, and controlling the expression of pro-inflammatory cytokines. To conclude, this review highlights that MK has great potential as a natural hepatoprotective agent, providing a versatile defense against a range of injuries caused by heavy metals, xenobiotics, and common hepatotoxic agents.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.