射频消融（RFA）是甲状腺结节（TN）的替代治疗方式，许多研究也证实了其良好的疗效和安全性。 RFA 的范围在临床实践中不断增加，我们研究的目的是评估 RFA 的疗效。我们于 2017 年 1 月至 2022 年 12 月在我们机构进行了一项前瞻性研究，以评估 RFA 对甲状腺结节的疗效。我们评估了 RFA 后淋巴结体积、减容率 (VRR)、技术有效 (TE) 率、完全消融 (CA) 率以及淋巴结再生率和时间的变化。2017 年 1 月至 2017 年 1 月期间，我们对 1703 例 TN 患者进行了 RFA 2022年12月，共有970名符合条件的患者参加了该研究。术前TNs体积为6.23±8.11ml，其中良性结节821个，恶性结节149个。 RFA 后 TE 和调整后 TE 率分别为 80% 和 88.8%。 145 名 (14.9%) 患者实现 CA，平均时间为 18.32±12.98 个月； 15 名 (1.5%) 患者出现淋巴结再生，平均时间为 29.80 ± 12.47 个月。 RFA 后第 1 年和第 2 年，TN 体积和 VRR 发生显着变化，并在 5 年后趋于稳定。一名颈交感神经链损伤的患者发生了严重的术后不良事件，导致霍纳综合征。由于缺乏术后喉镜检查，无法评估喉返神经的短暂性或永久性损伤，这是该研究的一个重大局限性。扩大的RFA适应症对TNs也有效，长期无明显变化功效。版权所有 © 2024 传科、明、志登、欢。

Radiofrequency ablation (RFA) is an alternative modality for thyroid nodules (TNs) and many studies have also confirmed its favorable efficacy and safety. The scope of RFA increases in clinical practice and the aim of our study was to evaluate the efficacy of RFA.We conducted a prospective study to evaluate the efficacy of RFA for thyroid nodules between January 2017 and December 2022 at our institution. We assessed the change in nodal volume, volume reduction ratio (VRR), technique effective (TE) rate, complete ablation (CA) rate, and nodal regrowth rate and time after RFA.We performed RFA for 1703 patients with TNs between January 2017 and December 2022, of which a total of 970 eligible patients were enrolled in the study. The preoperative volume of TNs was 6.23 ± 8.11ml, with 821 benign and 149 malignant nodules. The post-RFA TE and adjusted TE rate were 80% and 88.8%, respectively. CA was achieved in 145 (14.9%) patients with a mean time of 18.32± 12.98 months; nodal regrowth occurred in 15 (1.5%) patients with a mean time of 29.80 ± 12.47 months. TNs volume and VRR changed significantly at years 1 and 2 after RFA and stabilized after 5 years. A serious postoperative adverse event occurred in one patient with cervical sympathetic chain injury resulting in Horner's syndrome. A transient or permanent damage of the recurrent laryngeal nerve could not be evaluated due to the lack of postoperative laryngoscopy, and this is a significant limitation of the study.The expanded RFA indications were also effective for TNs, with no significant change in long-term efficacy.Copyright © 2024 Chuanke, Ming, Zhideng and Huan.