可改变的心血管危险因素是癌症患者心血管疾病和死亡的重要原因。最近的研究表明，社区步行适宜性与一般人群中有利的心血管危险因素之间存在潜在联系。本研究旨在调查社区步行适宜性是否与有癌症病史的患者中有利的心血管危险因素相关。我们进行了横断面研究该研究使用休斯顿卫理公会学习健康系统门诊登记处（2016-2022 年）的数据，该登记处包括 1,171,768 名 18 岁及以上的成年人。社区步行适宜性根据 2019 年步行得分确定，分为 4 类。有癌症病史的患者通过国际疾病分类第 10 版临床修改代码 (C00-C96) 进行识别。我们研究了癌症患者中可改变的心血管危险因素（高血压、糖尿病、吸烟、血脂异常和肥胖）与社区步行能力类别之间的患病率和关联。该研究纳入了 121,109 名有癌症病史的患者； 56.7%为女性患者，68.8%为非西班牙裔白人，平均年龄为67.3岁。与居住在最不适合步行的社区的参与者相比，居住在最适合步行的社区的参与者中可改变的心血管危险因素的患病率较低（分别为 76.7% 和 86.0%）。与依赖汽车出行的社区相比，居住在非常适合步行的社区的有癌症病史的患者出现任何危险因素的可能性要低 16%（调整后 OR：0.84，95% CI：0.78-0.92）。考虑事件发生时间的敏感性分析得出了类似的结果。我们的研究结果表明，在有癌症病史的患者中，社区步行能力与可改变的心血管危险因素负担之间存在关联。对步行社区的投资可能会提供一个可行的机会，以减轻有癌症病史的患者因可改变的心血管危险因素而日益增加的负担。© 2024 作者。

Modifiable cardiovascular risk factors constitute a significant cause of cardiovascular disease and mortality among patients with cancer. Recent studies suggest a potential link between neighborhood walkability and favorable cardiovascular risk factor profiles in the general population.This study aimed to investigate whether neighborhood walkability is correlated with favorable cardiovascular risk factor profiles among patients with a history of cancer.We conducted a cross-sectional study using data from the Houston Methodist Learning Health System Outpatient Registry (2016-2022) comprising 1,171,768 adults aged 18 years and older. Neighborhood walkability was determined using the 2019 Walk Score and divided into 4 categories. Patients with a history of cancer were identified through International Classification of Diseases-10th Revision-Clinical Modification codes (C00-C96). We examined the prevalence and association between modifiable cardiovascular risk factors (hypertension, diabetes, smoking, dyslipidemia, and obesity) and neighborhood walkability categories in cancer patients.The study included 121,109 patients with a history of cancer; 56.7% were female patients, and 68.8% were non-Hispanic Whites, with a mean age of 67.3 years. The prevalence of modifiable cardiovascular risk factors was lower among participants residing in the most walkable neighborhoods compared with those in the least walkable neighborhoods (76.7% and 86.0%, respectively). Patients with a history of cancer living in very walkable neighborhoods were 16% less likely to have any risk factor compared with car-dependent-all errands neighborhoods (adjusted OR: 0.84, 95% CI: 0.78-0.92). Sensitivity analyses considering the timing of events yielded similar results.Our findings demonstrate an association between neighborhood walkability and the burden of modifiable cardiovascular risk factors among patients with a medical history of cancer. Investments in walkable neighborhoods may present a viable opportunity for mitigating the growing burden of modifiable cardiovascular risk factors among patients with a history of cancer.© 2024 The Authors.