成人中最常见的原发性脑肿瘤是神经胶质瘤。除了治疗方案不足之外，神经胶质瘤的致命性主要是由于肿瘤细胞的快速增殖和持续浸润到周围的健康脑组织。根据越来越多的研究，有氧糖酵解或瓦伯格效应促进神经胶质瘤的发展，因为神经胶质瘤是经历代谢重编程的异质癌症。因此，解决瓦尔堡效应可能是治疗癌症的一种有用的治疗策略。乳酸在重新编程能量代谢中发挥着关键作用，使细胞能够快速获取大量能量。因此，乳酸是糖酵解的副产物，存在于快速增殖的细胞和肿瘤中。除了乳酸合成、循环和消耗的促肿瘤发生途径外，最近的研究还发现了乳酸诱导的乳酰化。乳酸在调节免疫过程、维持体内平衡和促进肿瘤代谢重编程方面发挥着至关重要的作用，这些过程是由乳酸诱导的组蛋白赖氨酸残基乳酰化调节的。在本文中，我们讨论了乳酰化的发现和影响，回顾了已发表的关于蛋白质乳酰化如何影响癌症生长的研究，并进一步探索通过靶向乳酰化来改善抗肿瘤效果的新治疗方法。这些发现可能会为改善神经胶质瘤患者的预后提供新的方法和指导。版权所有 © 2024 Liu、Zhou 和 Wang。

The most prevalent primary brain tumors in adults are gliomas. In addition to insufficient therapeutic alternatives, gliomas are fatal mostly due to the rapid proliferation and continuous infiltration of tumor cells into the surrounding healthy brain tissue. According to a growing body of research, aerobic glycolysis, or the Warburg effect, promotes glioma development because gliomas are heterogeneous cancers that undergo metabolic reprogramming. Therefore, addressing the Warburg effect might be a useful therapeutic strategy for treating cancer. Lactate plays a critical role in reprogramming energy metabolism, allowing cells to rapidly access large amounts of energy. Lactate, a byproduct of glycolysis, is therefore present in rapidly proliferating cells and tumors. In addition to the protumorigenesis pathways of lactate synthesis, circulation, and consumption, lactate-induced lactylation has been identified in recent investigations. Lactate plays crucial roles in modulating immune processes, maintaining homeostasis, and promoting metabolic reprogramming in tumors, which are processes regulated by the lactate-induced lactylation of the lysine residues of histones. In this paper, we discuss the discovery and effects of lactylation, review the published studies on how protein lactylation influences cancer growth and further explore novel treatment approaches to achieve improved antitumor effects by targeting lactylation. These findings could lead to a new approach and guidance for improving the prognosis of patients with gliomas.Copyright © 2024 Liu, Zhou and Wang.