多形性胶质母细胞瘤（GBM）是最常见的原发性恶性脑肿瘤，以其具有挑战性的预后而闻名。声动力疗法 (SDT) 是一种创新的治疗方法，通过低强度超声激活声敏剂，有望消除肿瘤。在这项研究中，使用铜掺杂碳点（Cu-CD）合成了一种新型声敏剂，用于 GBM 的声动力治疗。掺杂铜可将碳点转变为带隙为 1.58 eV 的 p-n 型半导体，寿命延长至 10.7 µs，并提高电子和空穴分离效率。声动力效应的效率得到提高。蛋白质印迹分析表明，Cu-CD 会诱导导致细胞死亡的生物反应，称为铜凋亡。具体来说，Cu-CDs 上调二氢硫基转乙酰酶的表达，从而与 SDT 结合时建立针对肿瘤细胞死亡的协同治疗作用。此外，Cu-CDs 具有优异的血脑屏障渗透性和有效的抗肿瘤活性。重要的是，Cu-CD 能有效阻止胶质母细胞瘤的生长，并延长携带这些肿瘤的小鼠的生存期。这项研究为碳基纳米材料作为声敏剂在肿瘤治疗中的应用提供了支持。© 2024 作者。 《Advanced Science》由 Wiley‐VCH GmbH 出版。

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) is an innovative therapeutic approach that shows promise in tumor elimination by activating sonosensitizers with low-intensity ultrasound. In this study, a novel sonosensitizer is synthesized using Cu-doped carbon dots (Cu-CDs) for the sonodynamic treatment of GBM. Doping with copper transforms the carbon dots into a p-n type semiconductor having a bandgap of 1.58 eV, a prolonged lifespan of 10.7 µs, and an improved electron- and hole-separation efficiency. The sonodynamic effect is efficiency enhanced. Western blot analysis reveals that the Cu-CDs induces a biological response leading to cell death, termed as cuproptosis. Specifically, Cu-CDs upregulate dihydrosulfanyl transacetylase expression, thereby establishing a synergistic therapeutic effect against tumor cell death when combined with SDT. Furthermore, Cu-CDs exhibit excellent permeability through the blood-brain barrier and potent anti-tumor activity. Importantly, the Cu-CDs effectively impede the growth of glioblastoma tumors and prolong the survival of mice bearing these tumors. This study provides support for the application of carbon-based nanomaterials as sonosensitizers in tumor therapy.© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.