组织张力包括施加在动物体内固体组织上的机械力，其来源多种多样，例如细胞收缩力、与邻近细胞和细胞外基质的相互作用。新的证据表明，这种力量的不平衡会影响结构组织、体内平衡，并可能导致疾病。例如，组织张力升高会阻碍顶端细胞的挤出，导致凋亡或转化细胞的保留。在这项研究中，我们研究了腺瘤性大肠杆菌（APC）在调节组织张力中的潜在作用。我们的研究结果表明，APC 截短突变体的表达通过 RhoA/ROCK 途径升高上皮张力。这种升高会引起形态改变并阻碍培养的上皮细胞和类器官中的凋亡细胞挤出，这两种情况都可以通过药理学恢复组织张力来减轻。这提出了 APC 突变可能通过改变组织力学发挥致病作用的可能性。© 2024 作者。细胞骨架由 Wiley periodicals LLC 出版。

Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and potentially contribute to disease. For instance, heightened tissue tension can impede apical cell extrusion, leading to the retention of apoptotic or transformed cells. In this study, we investigate the potential role of adenomatous polyposis coli (APC) in modulating tissue tension. Our findings reveal that expression of an APC truncation mutant elevates epithelial tension via the RhoA/ROCK pathway. This elevation induces morphological alterations and hampers apoptotic cell extrusion in cultured epithelial cells and organoids, both of which could be mitigated by pharmacologically restoring the tissue tension. This raises the possibility that APC mutations may exert pathogenetic effects by altering tissue mechanics.© 2024 The Author(s). Cytoskeleton published by Wiley Periodicals LLC.