表儿茶素 (Epi) 是不同水果和茶叶中最丰富的黄酮类化合物之一。新兴研究阐明了儿茶素在不同器官中抵御砷 (As) 暴露的破坏性影响的巨大潜力。本研究旨在了解 Epi 是否在小鼠模型中对砷引起的神经毒性具有治疗功效。医学研究所 (NMRI) 小鼠被随机分为 6 个不同组，其中包括接受生理盐水的对照组、连续 5 周每日口服砷 (10 mg/kg) 的组、接受 As (10 mg/kg) 的组。 kg/天）口服 5 周，最后 2 周口服不同剂量的 Epi（25-100 mg/kg），一组口服 Epi（100 mg/kg）2 周。为了评估 Epi 的潜在影响，我们对神经行为测试、氧化应激和炎症的各种参数进行了评估。这项研究的结果表明，As 诱导的神经行为毒性与脂质过氧化和一氧化氮 (NO) 浓度的显着升高有关，伴随着抗氧化标记物水平的降低。观察到包括肿瘤坏死因子-α (TNF-α) 在内的促炎细胞因子水平升高，同时观察到核因子 kappa B (NF-κB) 和核因子红细胞 2 相关因子 2 (Nrf2) 表达增强。然而，Epi 治疗逆转了这些影响。总的来说，这些发现表明 Epi 可能通过改善抗氧化状态、减轻氧化应激和炎症来对 As 诱导的神经毒性发挥治疗功效。尽管如此，还需要进一步的研究来全面掌握 Epi 在这种特定情况下的潜在保护作用。© 2024。作者获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Epicatechin (Epi) is one of the most abundant flavonoids present in different fruits and tea leaves. Emerging research illuminates the promising potential of catechins to serve as a shield against the damaging effects of arsenic (As) exposure in diverse organs.This study sought to discern whether Epi exhibits a therapeutic efficacy against arsenic-induced neurotoxicity in a murine model.The Naval Medical Research Institute (NMRI) mice were randomly partitioned into six distinct groups, which included a control group receiving normal saline, a group receiving a daily oral dose of arsenic (10 mg/kg) for 5 weeks, groups receiving As (10 mg/kg/day) orally for 5 weeks along with different doses of Epi (25-100 mg/kg) orally for the last 2 weeks, and a group receiving Epi (100 mg/kg) orally for 2 weeks. To assess the potential effects of Epi, neurobehavioral tests, various parameters of oxidative stress, and inflammation were evaluated.The findings of this investigation revealed that As-induced neurobehavioral toxicity was associated with a notable surge in lipid peroxidation and nitric oxide (NO) concentration, accompanied by a reduction in the levels of antioxidant markers. As heightened pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) levels were observed alongside amplified nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2) expression. However, treatment with Epi reversed these effects.On the whole, these findings indicate that Epi may hold promise therapeutic efficacy on As-induced neurotoxicity by improving antioxidant status and mitigating oxidative stress and inflammation. Nevertheless, further research is imperative to comprehensively grasp the potential protective effects of Epi in this particular context.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.