该研究旨在评估枣子的免疫调节作用，枣子是摩洛哥人用来增强对病原体免疫力的传统药物。这项研究旨在评估这种水果对免疫细胞及其功能的影响。为了实现这一目标，我们使用枣提取物对脾细胞、胸腺细胞和巨噬细胞进行了测试，重点关注它们的功能：抗体产生、吞噬作用和 T 淋巴细胞毒性。结果表明，海枣果实水提物对体液免疫具有显着的免疫刺激作用。与对照细胞相比，它通过增强补体活性并将脾细胞（包括 B 淋巴细胞）增殖增加 142.5% 来实现这一目标。同样，在相同条件下，通过胸腺细胞活性显着刺激细胞免疫，导致细胞增殖显着增加（225%）和胸腺细胞功能增强（245.9%），从而起到预防癌症的作用。此外，枣子提取物还具有抗炎特性。这在乙酸乙酯提取物下巨噬细胞介导的吞噬活性增加中显而易见，从而有效地消除病原体。评估枣提取物的美容潜力表明，乙酸乙酯提取物具有抗炎和强抗氧化作用，对紫外线 B 射线具有较高的光吸收能力。基于这些发现，我们建议研究该提取物作为防晒霜的用途。此外，傅里叶变换红外光谱分析表明，存在的最活跃的化合物是类黄酮。这些结果证实了这种水果增强免疫力的传统用途。版权所有©，埃及免疫学家协会。

The study aimed to assess the immunomodulatory effects of Phoenix dactylifera (dates) fruit, a traditional remedy used by Moroccans to enhance immunity against pathogens. This research sought to evaluate the impacts of this fruit on immune cells and their functions. To achieve this, we conducted tests using date extracts on splenocytes, thymocytes, and macrophages, focusing on their functions: antibody production, phagocytosis, and T-lymphocyte toxicity. The results obtained demonstrated that the aqueous extract of P. dactylifera fruit exhibited significant immunostimulatory effects on humoral immunity. It achieved this by enhancing complement activity and increasing splenocyte (including B-lymphocytes) proliferation by 142.5% compared to control cells. Similarly, in the same conditions, there was notable stimulation of cellular immunity through thymocyte activity, resulting in a remarkable increase in cell proliferation (225%) and a boost in thymocyte function (245.9%), which plays a role in safeguarding against cancer. Moreover, the date extract demonstrated anti-inflammatory properties. This was evident in the increased phagocytosis activity mediated by macrophages under the ethyl acetate extract, effectively eliminating pathogens. Assessing the cosmetic potential of date extracts showed that the ethyl acetate extract possesses both anti-inflammatory and strong antioxidant effects, exhibited high photo absorption of ultraviolet-B rays. Based on these findings, we propose to study the utilization of this extract for sun protection as a sunscreen. Furthermore, the Fourier-transform infrared spectroscopy analysis indicated that the most active compounds present were flavonoids. These outcomes substantiate the traditional usage of this fruit for reinforcing immunity.Copyright© by the Egyptian Association of Immunologists.