侵袭体是一个总称术语，用于描述包括足体和侵袭足在内的一系列细胞结构。它们作为细胞质膜和细胞外基质之间的接触区，有助于通过局部富集的蛋白水解酶进行基质重塑。侵袭小体是肌动蛋白依赖性的，参与促进粘附、迁移和侵袭的细胞过程。侵袭体存在于各种细胞类型中，在血管形成和骨吸收等生理现象中发挥着至关重要的作用。侵袭体还涉及病理过程，例如转移性肿瘤细胞侵袭期间的基质组织重塑。本综述总结了足体和侵袭足形成机制、其组织和功能的基本信息和最新进展。© 2024 médecine/sciences – Inserm。

Invadosome is an umbrella term used to describe a family of cellular structures including podosomes and invadopodia. They serve as contact zones between the cell plasma membrane and extracellular matrix, contributing to matrix remodeling by locally enriched proteolytic enzymes. Invadosomes, which are actin-dependent, are implicated in cellular processes promoting adhesion, migration, and invasion. Invadosomes, which exist in various cell types, play crucial roles in physiological phenomena such as vascularization and bone resorption. Invadosomes are also implicated in pathological processes such as matrix tissue remodeling during metastatic tumor cell invasion. This review summarizes basic information and recent advances about mechanisms underlying podosome and invadopodia formation, their organization and function.© 2024 médecine/sciences – Inserm.