广东相思子（Abrus cantoniensis Hance，ACH），又名鸡骨草，在民族药理学中的应用历史悠久，具有清热、疏肝的功效，尤其对治疗急、慢性肝炎十分有效。在我国南方地区，如广东、广西等地，人们经常使用ACH泡汤或花草茶作为食疗。本文旨在对ACH的民族药理学、植物化学物质和药理活性进行系统综述，同时也希望为更多的研究提供参考。通过PubMed、万方数据库、CNKI、Web of Science、EBSCO数据库、Google Scholar检索相关中英文文献，关键词“Abrus cantoniensis, Abrus cantoniensis Hance, Jigucao, druglogy” 《化学成分、临床应用、网络药理学》单独或联合使用。传统上认为ACH具有疏肝、清热、解毒的功效，常用于治疗肝脏疾病和炎症。现代药理研究表明ACH具有保肝、抗炎、抗氧化、免疫调节、抗肿瘤等作用。无论是单一化合物还是ACH提取物，研究发现其具有丰富的药理活性，这是保肝、抗炎等传统用途的根本来源。系统综述发现，现代植物化学和药效研究关于ACH的报道与其传统用途密切相关，尤其是其保肝和抗炎作用。现代研究也进一步探索和拓展了ACH的作用，例如其抗肿瘤作用。所有这些努力正在逐步填补传统用途与现代药理学之间的空白。总的来说，目前ACH的药效机制研究还需要进一步深入研究，采取的策略也必须进一步加强。Copyright © 2024. Published by Elsevier B.V.

Abrus cantoniensis Hance (ACH), known as Ji Gu Cao (Chinese: ) has been used in ethnopharmacology for a long history with therapeutic effects for clearing heat, soothing the liver, especially in treating acute and chronic hepatitis which was very effective. In southern China, such as Guangdong and Guangxi, people often use ACH in soup or herbal tea as dietetic therapy.This paper aims to review ACH's ethnopharmacology, phytochemicals, and pharmacological activity systematically, at the same time, we also hope to provide more research avenues between traditional uses and pharmacological properties.Through PubMed, Wan Fang Database, CNKI, Web of Science, EBSCO Database, and Google Scholar search for relevant literature in both Chinese and English, the keywords "Abrus cantoniensis, Abrus cantoniensis Hance, Jigucao, pharmacology, chemical constituents, clinical application, Network Pharmacology" were used alone or combination.Traditionally, ACH was believed to have the effect of soothing the liver, clearing heat, and detoxifying, often used to treat diseases of the liver and inflammation. Modern pharmacological research indicates that ACH has liver protection, anti-inflammation, anti-oxidant, immunomodulation, anti-tumor effects and so on. Whether it was a single chemical compound or an extract from ACH, studies have found that it has abundant pharmacological activities, these were the fundamental sources of traditional uses, like liver protection and anti-inflammation.A systematic review found that modern phytochemistry and pharmacodynamic research reports on ACH are closely related to its traditional use, especially its hepatoprotective and anti-inflammatory effects. Modern research has also further explored and expanded the effects of ACH, such as its anti-tumor effect. And all these efforts are gradually filling the gap between traditional uses and modern pharmacology. In general, the current research on the pharmacodynamic mechanism of ACH still needs further in-depth research, and the strategies adopted must also be further strengthened.Copyright © 2024. Published by Elsevier B.V.