吲哚菁绿是一种 FDA 批准的荧光成像染料，用于测定心输出量、肝功能、肝脏血流量和视网膜灌注。它已在光声成像和光热疗法（PTT）中进行了临床前研究；然而，ICG 的光降解限制了其生物医学应用。 ICG 的聚集形式称为 J-聚集体 (IJA)，与单体 ICG 相比，表现出优异的光声信号和热稳定性。尽管如此，IJA仍然存在生物环境稳定性差、体内血液循环短等问题。为了解决这些限制，开发了一系列纳米载体来增强 IJA 的稳定性和性能。除了最近开发的 IJA 负载纳米载体（特别是用于癌症成像和治疗）之外，本综述还重点讨论了 IJA 的潜力和局限性。版权所有 © 2024。由 Elsevier B.V. 出版。

Indocyanine green is an FDA-approved fluorescent imaging dye used for determining cardiac output, hepatic function, liver blood flow, and retinal perfusion. It has been investigated preclinically in photoacoustic imaging and photothermal therapy (PTT); however, ICG photodegradation limits its biomedical applications. An aggregated form of ICG, known as J-aggregate (IJA), exhibits superior photoacoustic signals and thermal stability than the monomeric ICG. Nevertheless, IJA still suffers from low stability in the biological milieu, and short in vivo blood circulation. To address these limitations, a range of nanocarriers have been developed to enhance IJA stability and performance. This review focuses on IJA potentials and limitations, besides the recent development of IJA-loaded nanocarriers, particularly for cancer imaging and therapy.Copyright © 2024. Published by Elsevier B.V.