妊娠相关乳腺癌 (PABC) 治疗后，一些女性希望未来怀孕。虽然乳腺癌后怀孕的安全性已得到证实，但对于患有 PABC 的女性却不能说同样的情况。本研究的目的是描述与没有再次怀孕的患者相比，随后怀孕的 PABC 患者的发病率和结果。回顾性图表审查确定了 2011 年至 2023 年期间怀孕期间或产后 5 年内诊断出患有乳腺癌的患者。然后对患者进行了进一步怀孕的筛查。记录临床病理变量、肿瘤学结果和妊娠结果。卡方检验和 t 检验用于比较随后妊娠的患者与未妊娠的患者。使用 Kaplan-Meier 方法和对数秩检验来估计 5 年无病生存率 (DFS)。 总体而言，确定了 75 名 PABC 患者，其中 58 名患有 PABC 且没有进一步妊娠 (NSP-PABC)，17 名患有 PABC 患者。随后怀孕（SP-PABC）。与 NSP-PABC 患者相比，SP-PABC 患者明显更年轻 (p = 0.015)，且以前怀孕的可能性较小 (p < 0.001)。总体中位随访时间为 4.3 年。 SP-PABC 组和 NSP-PABC 组的计算得出的 5 年 DFS 率分别为 86.2% 和 89.0% (p = 0.76)。 SP-PABC 和 NSP-PABC 组的计算得出的 5 年总生存率分别为 100% 和 90.7% (p = 0.22)。在 SP-PABC 组中，14/17 的患者成功分娩。本研究首次描述了 PABC 患者和随后的妊娠。需要进行额外的调查，可能需要来自多个机构的汇总分析，以确定 PABC 后妊娠的肿瘤学和产科安全性。© 2024。作者。

After treatment of pregnancy-associated breast cancer (PABC), some women desire future pregnancy. While safety of pregnancy after breast cancer has been demonstrated, the same cannot be said about women with PABC.The aim of this study was to describe the incidence and outcomes of patients with PABC with subsequent pregnancies compared with those without another pregnancy.A retrospective chart review identified patients diagnosed with breast cancer during pregnancy or within 5 years postpartum between 2011 and 2023. Patients were then screened for further pregnancy. Clinicopathologic variables, oncologic outcomes, and pregnancy outcomes were recorded. The Chi-square test and t-test were used to compare patients with subsequent pregnancy with those without. Kaplan-Meier method and log-rank test were used to estimate 5-year disease-free survival (DFS).Overall, 75 patients with PABC were identified, 58 of whom had PABC and no further pregnancies (NSP-PABC) and 17 with subsequent pregnancy (SP-PABC). Compared with patients with NSP-PABC, patients with SP-PABC were significantly younger (p = 0.015) and less likely to have prior pregnancies (p < 0.001). Overall median follow-up was 4.3 years. Calculated 5-year DFS rates were 86.2% and 89.0% for the SP-PABC and NSP-PABC groups, respectively (p = 0.76). Calculated 5-year overall survival was 100% and 90.7% for the SP-PABC and NSP-PABC groups, respectively (p = 0.22). Within the SP-PABC group, 14/17 patients had successful deliveries.This study provides the first descriptions of patients with PABC and subsequent pregnancy. Additional investigation, likely with pooled analysis from multiple institutions, is necessary to determine the oncologic and obstetric safety of pregnancy following PABC.© 2024. The Author(s).