调节细胞死亡 (RCD) 途径，例如焦亡、细胞凋亡和坏死性凋亡，对于维持身体平衡、防御病原体和消除可能导致癌症等疾病的异常细胞至关重要。尽管这些途径通过不同的机制发挥作用，但最近的遗传和药理学研究表明它们可以相互作用并相互影响。 “全凋亡”的概念已经出现，强调了细胞焦亡、细胞凋亡和坏死性凋亡之间的相互作用，特别是在细胞对感染的反应期间。本文简要概述了 PANoptosis 及其分子机制，探讨了其在各种疾病中的影响。该综述重点关注不同 RCD 通路之间的广泛相互作用，强调 PANoptosis 在感染、细胞因子风暴、炎症性疾病和癌症中的作用。了解全下垂对于开发治疗感染、无菌性炎症和癌症等疾病的新疗法至关重要。© 2024。韩国药学会。

Regulated cell death (RCD) pathways, such as pyroptosis, apoptosis, and necroptosis, are essential for maintaining the body's balance, defending against pathogens, and eliminating abnormal cells that could lead to diseases like cancer. Although these pathways operate through distinct mechanisms, recent genetic and pharmacological studies have shown that they can interact and influence each other. The concept of "PANoptosis" has emerged, highlighting the interplay between pyroptosis, apoptosis, and necroptosis, especially during cellular responses to infections. This article provides a concise overview of PANoptosis and its molecular mechanisms, exploring its implications in various diseases. The review focuses on the extensive interactions among different RCD pathways, emphasizing the role of PANoptosis in infections, cytokine storms, inflammatory diseases, and cancer. Understanding PANoptosis is crucial for developing novel treatments for conditions involving infections, sterile inflammations, and cancer.© 2024. The Pharmaceutical Society of Korea.