铁死亡是一种由铁介导的脂质过氧化积累引起的细胞死亡形式。铁死亡在不同病理生理条件下的参与为潜在的治疗干预提供了新的视角。天然产物因其在药物发现和再利用方面的重要性而被广泛认可，在通过针对各种铁死亡参与者来调节铁死亡方面显示出巨大的前景。在这篇综述中，我们讨论了铁死亡的调节机制及其在不同病理条件下的影响。我们剖析了天然产物与铁死亡在癌症、缺血/再灌注、神经退行性疾病、急性肾损伤、肝损伤和心肌病中的相互作用，重点是铁死亡参与者与疾病靶向性的相关性。© 2024。作者，获得 Springer-Verlag GmbH 德国（Springer Nature 旗下公司）的独家许可。

Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different pathophysiological conditions has offered new perspectives on potential therapeutic interventions. Natural products, which are widely recognized for their significance in drug discovery and repurposing, have shown great promise in regulating ferroptosis by targeting various ferroptosis players. In this review, we discuss the regulatory mechanisms of ferroptosis and its implications in different pathological conditions. We dissect the interactions between natural products and ferroptosis in cancer, ischemia/reperfusion, neurodegenerative diseases, acute kidney injury, liver injury, and cardiomyopathy, with an emphasis on the relevance of ferroptosis players to disease targetability.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.