机器人经口腔舌根粘膜切除术被引入作为原发灶不明的头颈癌（CUP）患者的诊断程序，提高了原发肿瘤的识别率。对于 CUP 的治疗，相当一部分患者需要辅助（化疗）放射治疗。本研究的目的是调查 TORS 和辅助治疗后 CUP 患者的吞咽结局。对调查 TORS 和辅助治疗对 CUP 患者吞咽相关结局影响的研究进行了系统回顾。此外，一项横断面研究对 TORS 和辅助治疗后 1-5 年到门诊就诊的常规护理 CUP 患者的吞咽问题（使用 SWAL-QOL 问卷测量）进行了研究。系统评价（6 项研究；n = 98）表明大多数患者恢复全口服饮食。横断面研究（n = 12）显示，所有患者均能够恢复全口饮食，但仍有 50% 的患者报告日常生活中有吞咽问题（SWAL-QOL 总分≥14）。尽管经过 TORS 和辅助治疗后对于CUP，可以恢复全口服饮食，但患者在日常生活中仍会遇到饮食问题。© 2024 作者。 《口腔疾病》由 Wiley periodicals LLC 出版。

Robotic transoral mucosectomy of the base of tongue was introduced as a diagnostic procedure in patients treated for head and neck cancer with unknown primary (CUP), increasing the identification rate of the primary tumour. For the treatment of CUP, a considerable percentage of patients require adjuvant (chemo)radiation. The aim of this study was to investigate swallowing outcomes among CUP patients after TORS and adjuvant treatment.A systematic review was carried out on studies investigating the impact of TORS and adjuvant treatment on swallowing-related outcomes among CUP patients In addition, a cross-sectional study was carried out on swallowing problems (measured using the SWAL-QOL questionnaire) among CUP patients in routine care who visited the outpatient clinic 1-5 years after TORS and adjuvant treatment.The systematic review (6 studies; n = 98) showed that most patients returned to a full oral diet. The cross-sectional study (n = 12) showed that all patients were able to return to a full oral diet, nevertheless, 50% reported swallowing problems in daily life (SWAL-QOL total score ≥14).Although after TORS and adjuvant treatment for CUP a full oral diet can be resumed, patients still experience problems with eating and drinking in daily life.© 2024 The Author(s). Oral Diseases published by Wiley Periodicals LLC.