肝脏疾病是一个重大的全球健康挑战，需要探索创新的治疗方式。脂质体纳米载体已成为靶向药物递送至肝脏的有希望的候选者。这篇综述对脂质体纳米载体在解决各种肝脏疾病方面的机制和应用进行了全面的研究。首先讨论肝脏疾病和常规治疗方法，该综述深入研究了脂质体的结构和成分。此外，它还解决了脂质体靶向的不同机制，包括被动和主动策略。此后，该综述继续探索脂质体纳米载体在治疗肝硬化、纤维化、病毒性肝炎和肝细胞癌方面的治疗潜力。通过讨论最新进展并展望未来前景，本综述强调了脂质体纳米载体在增强肝脏疾病的有效性和安全性，从而改善患者预后和提高生活质量方面的作用。

Liver disorders present a significant global health challenge, necessitating the exploration of innovative treatment modalities. Liposomal nanocarriers have emerged as promising candidates for targeted drug delivery to the liver. This review offers a comprehensive examination of the mechanisms and applications of liposomal nanocarriers in addressing various liver disorders. Firstly discussing the liver disorders and the conventional treatment approaches, the review delves into the liposomal structure and composition. Moreover, it tackles the different mechanisms of liposomal targeting including both passive and active strategies. After that, the review moves on to explore the therapeutic potentials of liposomal nanocarriers in treating liver cirrhosis, fibrosis, viral hepatitis, and hepatocellular carcinoma. Through discussing recent advancements and envisioning future perspectives, this review highlights the role of liposomal nanocarriers in enhancing the effectiveness and the safety of liver disorders and consequently improving patient outcomes and enhances life quality.