许多脑部疾病给人类生活带来严重挑战。阿尔茨海默病（AD）和帕金森病（PD）是严重威胁人类健康的常见神经退行性疾病。胶质瘤是一种常见的恶性肿瘤。然而，由于血脑屏障（BBB）和血脑肿瘤屏障（BBTB）的存在，药物无法跨越生理和病理屏障，大​​多数治疗药物无法进入大脑。如何使药物能够穿透BBB进入大脑，降低全身毒性，并穿透BBTB发挥治疗作用已成为一个挑战。纳米混悬剂可以利用表面活性剂作为稳定剂成功配制难溶于水和油的药物，适用于生物制药分类系统（BCS）中II类和IV类药物的脑靶向递送。在纳米混悬剂药物递送系统中，纳米结构的物理性质对药物在目标部位（例如大脑）的积累有很大影响。优化纳米混悬剂的物理参数可以提高脑部药物输送和疾病治疗的效率。因此，本文对纳米混悬剂增强脑药物输送的关键挑战、影响因素和未来前景进行了总结和综述。本文旨在更好地理解用于大脑输送的纳米混悬剂配方技术以及用于克服各种生理障碍的策略。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Many brain diseases pose serious challenges to human life. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common neurodegenerative diseases that seriously threaten human health. Glioma is a common malignant tumor. However, drugs cannot cross physiological and pathological barriers and most therapeutic drugs cannot enter the brain because of the presence of the Blood-brain Barrier (BBB) and Blood- -brain Tumor Barrier (BBTB). How to enable drugs to penetrate the BBB to enter the brain, reduce systemic toxicity, and penetrate BBTB to exert therapeutic effects has become a challenge. Nanosuspension can successfully formulate drugs that are difficult to dissolve in water and oil by using surfactants as stabilizers, which is suitable for the brain target delivery of class II and IV drugs in the Biopharmaceutical Classification System (BCS). In nanosuspension drug delivery systems, the physical properties of nanostructures have a great impact on the accumulation of drugs at the target site, such as the brain. Optimizing the physical parameters of the nanosuspension can improve the efficiency of brain drug delivery and disease treatment. Therefore, the key challenges, influencing factors, and future perspectives of nanosuspension in enhancing brain drug delivery are summarized and reviewed here. This article aims to provide a better understanding of nanosuspension formulation technology used for brain delivery and strategies used to overcome various physiological barriers.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.