具核梭杆菌是一种广泛存在于人类口腔中的革兰氏阴性厌氧细菌，由于其显着的聚集能力，被广泛认为是导致牙周疾病发生和进展的关键病原体。许多临床研究已将具核梭杆菌与各种恶性肿瘤的不良预后结果联系起来。在进一步的研究中，学者们已经部分阐明了具核梭杆菌对各类癌症影响的机制，从而对具核梭杆菌在癌症中的作用有了一定的认识。在这篇综合综述中，我们深入综合了具核梭菌与不同癌症之间的相互作用，重点关注肿瘤发生、转移、化疗耐药以及肿瘤免疫微环境和免疫治疗的调节等方面。还总结了对癌症诊断和治疗的影响。本综述的目的是增强我们对具核梭菌与致癌发病机制之间错综复杂关系的理解，同时强调潜在的治疗策略。© 2024 John Wiley

Fusobacterium nucleatum, a gram-negative anaerobic bacterium abundantly found in the human oral cavity, is widely recognized as a key pathobiont responsible for the initiation and progression of periodontal diseases due to its remarkable aggregative capabilities. Numerous clinical studies have linked F. nucleatum with unfavorable prognostic outcomes in various malignancies. In further research, scholars have partially elucidated the mechanisms underlying F. nucleatum's impact on various types of cancer, thus gaining a certain comprehension of the role played by F. nucleatum in cancer. In this comprehensive review, we present an in-depth synthesis of the interplay between F. nucleatum and different cancers, focusing on aspects such as tumor initiation, metastasis, chemoresistance, and modulation of the tumor immune microenvironment and immunotherapy. The implications for cancer diagnosis and treatment are also summarized. The objective of this review is to enhance our comprehension of the intricate relationship between F. nucleatum and oncogenic pathogenesis, while emphasizing potential therapeutic strategies.© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.