尤文氏肉瘤 (EWS) 是一种高度侵袭性的恶性骨肿瘤，主要影响青少年和年轻人。尽管放化疗在某些情况下有效，但转移性和复发性疾病患者的治愈率仍然很低。因此，迫切需要创新的治疗方法来解决与 EWS 治疗相关的挑战。表观遗传调控是生理过程中的关键因素，在控制细胞增殖、维持基因完整性和调节转录方面发挥着重要作用。最近的研究强调了异常表观遗传调控在 EWS 的发生和进展中的重要性。全面了解 EWS 与异常表观遗传调控之间复杂的相互作用对于推进临床药物开发至关重要。本综述旨在对 EWS 涉及的两个表观遗传靶点进行全面概述，整合各种治疗方式，为 EWS 的临床诊断和治疗提供创新视角。版权所有 ©2024 中国癌症研究杂志。版权所有。

Ewing's sarcoma (EWS) is a highly aggressive malignant bone tumor primarily affecting adolescents and young adults. Despite the efficacy of chemoradiotherapy in some cases, the cure rate for patients with metastatic and recurrent disease remains low. Therefore, there is an urgent need for innovative therapeutic approaches to address the challenges associated with EWS treatment. Epigenetic regulation, a crucial factor in physiological processes, plays a significant role in controlling cell proliferation, maintaining gene integrity, and regulating transcription. Recent studies highlight the importance of abnormal epigenetic regulation in the initiation and progression of EWS. A comprehensive understanding of the intricate interactions between EWS and aberrant epigenetic regulation is essential for advancing clinical drug development. This review aims to provide a comprehensive overview of both epigenetic targets implicated in EWS, integrating various therapeutic modalities to offer innovative perspectives for the clinical diagnosis and treatment of EWS.Copyright ©2024 Chinese Journal of Cancer Research. All rights reserved.