由于癌症患病率不断上升以及合成药物的有害副作用，天然产品正在被开发为可能的治疗选择。牛蒡子苷是一种天然存在的木酚素，存在于多种植物中，具有不同的药理活性以及抗癌作用。为了阐明抗癌特性和潜在的作用机制，使用适当的关键词对各种电子数据库进行了全面检索，以识别相关出版物。研究结果表明，在多项临床前药理学研究中，牛蒡子苷表现出抗肿瘤形成和各种癌症（如宫颈癌、骨髓瘤、前列腺癌、内皮癌、胃癌和结肠癌）的抗癌特性。这种天然存在的化合物通过不同的细胞机制发挥抗癌作用，包括线粒体功能障碍、细胞周期不同阶段（G2/M）、抑制细胞增殖、细胞凋亡和细胞毒性作用，以及抑制细胞迁移和侵袭。各种恶性细胞。此外，研究还发现，在各种细胞通路中，牛蒡子苷在PI3K/AKT和JAK/STAT信号通路方面表现出更强的作用。然而，药代动力学研究表明该化合物的口服生物利用度较差。由于这些发现，牛蒡子苷可能被认为是一种有前途的候选化疗药物。© 2024 作者。

Natural products are being developed as possible treatment options due to the rising prevalence of cancer and the harmful side effects of synthetic medications. Arctiin is a naturally occurring lignan found in numerous plants and exhibits different pharmacological activities, along with cancer. To elucidate the anticancer properties and underlying mechanisms of action, a comprehensive search of various electronic databases was conducted using appropriate keywords to identify relevant publications. The findings suggest that arctiin exhibits anticancer properties against tumor formation and various cancers such as cervical, myeloma, prostate, endothelial, gastric, and colon cancers in several preclinical pharmacological investigations. This naturally occurring compound exerts its anticancer effect through different cellular mechanisms, including mitochondrial dysfunction, cell cycle at different phases (G2/M), inhibition of cell proliferation, apoptotic cell death, and cytotoxic effects, as well as inhibition of migration and invasion of various malignant cells. Moreover, the study also revealed that, among the various cellular pathways, arctiin was shown to be more potent in terms of the PI3K/AKT and JAK/STAT signaling pathways. However, pharmacokinetic investigation indicated the compound's poor oral bioavailability. Because of these findings, arctiin might be considered a promising chemotherapeutic drug candidate.© 2024 The Authors.