本研究旨在系统地回顾关于体重诊断不同但牙周状况相似的个体通过细胞因子和趋化因子测量的炎症特征的文献。在五个数据库（Scopus、EMBASE、PubMed、Web of Science）中进行了搜索和 Cochrane 中心）。纳入的研究比较了正常体重个体和肥胖个体的炎症特征，并评估了相同的细胞因子、收集方法和牙周诊断（牙周健康、牙龈炎或牙周炎）。独立研究人员使用乔安娜布里格斯研究所批判性评估清单对横断面研究进行了评估。 GRADE（推荐、评估、发展和评估等级）系统评估了证据的确定性。纳入了十二项研究。肥胖的诊断是根据体重指数、腰围和腰臀比进行的。分析血清、唾液、龈沟液 (GCF) 中的促炎细胞因子（白介素-6 [IL-6]、肿瘤坏死因子-α [TNF]-α、IL-1β、IL-31 和 IL-34） ）和血浆。不同研究的牙周诊断各不相同。肥胖且牙周健康或牙周炎的个体中 TNF-α 表达显着较高。血清 IL-1β 水平显示出不同的结果，但肥胖个体的唾液 IL-1β 水平升高。无论牙周状况如何，肥胖个体的 IL-6 水平较高。 IL-34 和 IL-10 在各组之间没有显着差异。患有牙周炎或牙周健康的肥胖个体的单核细胞趋化蛋白 4 (MCP-4) 水平较高。 GCF 中的 IL-31 和 IL-34 在肥胖和非肥胖个体之间没有显着差异，无牙周炎。IL-6、IL-1β、IL-31、IL-34、TNF-α 和 MCP- 的结果存在异质性。 4，阻碍关于体重对牙周患者炎症特征影响的结论。版权所有：© 2024 印度牙周病学会。

This study aimed to systematically review the literature regarding the inflammatory profiles, measured by cytokines and chemokines, of individuals with different diagnoses of weight, but with the similar periodontal condition.Searches were performed in five databases (Scopus, EMBASE, PubMed, Web of Science, and Cochrane-Central). Studies that compared the inflammatory profile of normal-weight individuals to those with obesity and evaluated the same cytokine, collection method, and periodontal diagnosis (periodontal health, gingivitis, or periodontitis) were included. Cross-sectional studies underwent evaluation by independent researchers using the Joanna Briggs Institute Critical Appraisal Checklist. The GRADE (Grades of Recommendation, Assessment, Development and Evaluation) system assessed evidence certainty.Twelve studies were included. The diagnosis of obesity was done on the basis of body mass index, waist circumference, and waist-hip ratio. Pro-inflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor-α [TNF]-α, IL-1β, IL-31, and IL-34) were analyzed in serum, saliva, gingival crevicular fluid (GCF), and plasma. Periodontal diagnoses varied across studies. TNF-α expression was significantly higher in individuals with obesity and periodontal health or periodontitis. Serum IL-1β levels showed mixed results, but salivary IL-1β levels were elevated in obese individuals. IL-6 levels were higher in obese individuals, regardless of periodontal status. IL-34 and IL-10 showed no significant differences across groups. Monocyte chemoattractant protein-4 (MCP-4) levels were higher in obese individuals with periodontitis or periodontal health. IL-31 and IL-34 in GCF showed no significant differences between obese and nonobese individuals, without periodontitis.Heterogeneous results were noted for IL-6, IL-1β, IL-31, IL-34, TNF-α, and MCP-4, hindering conclusions on weight's impact on inflammatory profiles in periodontal patients.Copyright: © 2024 Indian Society of Periodontology.