类器官是维持自身组织结构和功能的体外 3D 模型。它们在很大程度上克服了传统肿瘤模型的局限性，近年来已成为肿瘤学领域强大的研究工具。妇科恶性肿瘤是严重威胁妇女生命健康的重大疾病，迫切需要建立与人类肿瘤高度相似的模型进行临床研究，制定个体化治疗方案。目前，类器官作为药物筛选和个体化医疗的手段，在探索妇科肿瘤发生机制方面得到了广泛的研究。卵巢癌、子宫内膜癌、宫颈癌作为妇科常见恶性肿瘤，其发病率和死亡率均居妇科肿瘤之首。因此，本研究综述了建模、药效评估和药物反应预测在卵巢癌、子宫内膜癌和宫颈癌中的应用，从而阐明肿瘤发生发展的机制，为妇科肿瘤患者提供精准的治疗方案。版权所有 © 2024 Shen 、王、王、李、韩。

Organoids are in vitro 3D models that maintain their own tissue structure and function. They largely overcome the limitations of traditional tumor models and have become a powerful research tool in the field of oncology in recent years. Gynecological malignancies are major diseases that seriously threaten the life and health of women and urgently require the establishment of models with a high degree of similarity to human tumors for clinical studies to formulate individualized treatments. Currently, organoids are widely studied in exploring the mechanisms of gynecological tumor development as a means of drug screening and individualized medicine. Ovarian, endometrial, and cervical cancers as common gynecological malignancies have high morbidity and mortality rates among other gynecological tumors. Therefore, this study reviews the application of modelling, drug efficacy assessment, and drug response prediction for ovarian, endometrial, and cervical cancers, thereby clarifying the mechanisms of tumorigenesis and development, and providing precise treatment options for gynecological oncology patients.Copyright © 2024 Shen, Wang, Wang, Li and Han.