食管鳞状细胞癌（ESCC）是我国高发的恶性肿瘤。由于缺乏有效的分子靶点，食管鳞癌患者的预后较差。迫切需要探索食管鳞癌的发病机制，以确定有希望的治疗靶点。代谢重编程是食管鳞癌的一个新兴标志，为揭示食管鳞癌的生物学特征提供了新的视角。在缺氧和营养有限的肿瘤微环境中，食管鳞癌细胞必须重新编程其代谢表型，以满足食管鳞癌细胞的生物能、生物合成和氧化还原稳态的需求。在这篇综述中，我们总结了食管鳞癌细胞的代谢重编程，包括葡萄糖代谢、脂质代谢和氨基酸代谢，并探讨了重编程代谢如何为食管鳞癌的生物标志物和潜在治疗靶点带来新的机会。版权所有 © 2024 Wang, Sun, Li,于、李、徐。

Esophageal squamous cell carcinoma (ESCC) is a malignancy with high incidence in China. Due to the lack of effective molecular targets, the prognosis of ESCC patients is poor. It is urgent to explore the pathogenesis of ESCC to identify promising therapeutic targets. Metabolic reprogramming is an emerging hallmark of ESCC, providing a novel perspective for revealing the biological features of ESCC. In the hypoxic and nutrient-limited tumor microenvironment, ESCC cells have to reprogram their metabolic phenotypes to fulfill the demands of bioenergetics, biosynthesis and redox homostasis of ESCC cells. In this review, we summarized the metabolic reprogramming of ESCC cells that involves glucose metabolism, lipid metabolism, and amino acid metabolism and explore how reprogrammed metabolism provokes novel opportunities for biomarkers and potential therapeutic targets of ESCC.Copyright © 2024 Wang, Sun, Li, Yu, Li and Xu.