干细胞移植是一种用于治疗某些类型癌症（例如血液恶性肿瘤）的临床方法。移植物抗宿主病 (GVHD) 发生在 30-70% 的病例中，通常会降低移植患者的生活质量。本研究旨在确定造血干细胞移植后 GVHD 阴道并发症的发生率。本研究采用分析横断面设计。 2019 年至 2020 年间转诊至德黑兰 Shariati 医院并接受造血干细胞移植的所有患者，如果符合纳入标准，则考虑纳入本研究。纳入标准包括 18-70 岁、100 多天前接受干细胞移植的非性活跃女性。排除标准包括在移植后 100 天内经历 GVHD 的患者。此外，还排除了75岁以上的个体和转移性癌症患者。总共招募了55名患者，受者的平均年龄为40±9.9岁，供者的平均年龄为38.5±12.8岁。值得注意的是，分别有 63.3% 和 58.2% 的患者出现口腔和眼部症状。至于生殖器受累，49.1%的人有阴道症状，25.5%的人有外阴受累。在 27 例阴道受累患者中，轻度受累 2 例（7.4%），中度受累 17 例（63%），重度受累 8 例（29.6%）。单变量分析确定阴道分泌物减少[优势比（OR=6.56）]、阴道紧缩（OR=6.23）、盆腔疼痛（OR=5.50）和阴道受累（OR=3.81）是其他器官症状的显着预测因素。此外，阴道受累（OR=3.68）成为口腔、眼部和其他器官症状同时发生的唯一重要预测因素。在多变量分析中，阴道分泌物减少 (OR=8.24) 和阴道紧缩 (OR=3.92) 可显着预测其他器官症状 (P=0.009)。阴道分泌物减少和阴道紧缩仍然是其他器官症状的重要预测因素。版权所有 © 2024作者。由 Wolters Kluwer Health, Inc. 出版

Stem cell transplantation is a clinical approach used to treat certain types of cancers, such as hematologic malignancies. Graft-versus-host disease (GVHD) occurs in 30-70% of cases and often diminishes the quality of life of transplant patients. This study aimed to determine the prevalence of vaginal complications of GVHD following hematopoietic stem cell transplantation.This study employed an analytical cross-sectional design. All patients referred to Shariati Hospital in Tehran between 2019 and 2020 who underwent hematopoietic stem cell transplantation were considered for inclusion in this study if they met the inclusion criteria. Inclusion criteria encompassed nonnot sexually active women aged 18-70 who received stem cell transplantation more than 100 days prior. Exclusion criteria comprised patients who experienced GVHD during the first 100 days posttransplantation. Additionally, individuals over 75 and patients with metastatic cancer were excluded.A total of 55 patients were recruited, with ages averaging 40±9.9 years for recipients and 38.5±12.8 years for donors. Notably, 63.3 and 58.2% of patients exhibited oral and ocular symptoms, respectively. Regarding genital involvement, 49.1% experienced vaginal symptoms, while 25.5% had vulvar involvement. Among the 27 patients with vaginal involvement, two (7.4%) were categorized as mild, 17 (63%) as moderate, and eight (29.6%) as severe. Univariate analysis identified reduced vaginal discharge [odds ratio (OR=6.56)], vaginal tightness (OR=6.23), pelvic pain (OR=5.50), and vaginal involvement (OR=3.81) as significant predictors of other organ symptoms. Moreover, vaginal involvement (OR=3.68) emerged as the sole significant predictor of the cooccurrence of oral, ocular, and other organ symptoms. In the multivariate analysis, reduced vaginal discharge (OR=8.24) and vaginal tightness (OR=3.92) significantly predicted other organ symptoms (P=0.009).Reduced vaginal discharge and vaginal tightness remained significant predictors of other organ symptoms.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.