全身炎症评分（SIS）是一种基于淋巴细胞与单核细胞比率（LMR）和血清白蛋白浓度相结合的新炎症标志物，据报道是多种恶性肿瘤的有用预后标志物。作者对一组接受潜在治愈性切除的食管癌患者的数据进行了这项回顾性研究，以阐明 SIS 作为该人群临床结果预后标志物的价值。这项回顾性队列研究包括 32 名在新辅助化疗后接受胸腔镜食管切除术的患者2016 年 1 月至 2019 年 12 月期间的食管癌患者。在开始术前化疗前一周内采集血样。三种炎症和营养标记物；本研究检查了 SIS、中性粒细胞与淋巴细胞比率 (NLR) 和预后营养指数 (PNI)。采用Kaplan-Meier法评估无病生存率，并应用单变量和多变量Cox模型评估SIS、NLR和PNI的预测价值。NLR和PNI与复发无关，而SIS评分为1和2则与复发相关。与复发显着相关。在多变量分析中，发现 SIS 评分为 1 或 2 与复发独立相关，各自的风险比为 1.98。此外，在检查免疫、营养因素和生存率时，NLR和PNI的生存率没有显着差异；然而，对于 SIS，SIS 评分为 1 或 2 的患者的生存率明显较差。作者证明，一种基于治疗前血清白蛋白和 LMR 的新颖且易于获得的预后评分（称为 SIS）可以作为一种预测评分。食管癌术后患者的独立预后因素。它可以被纳入传统的临床和病理算法中，以提高该人群的预后准确性。版权所有 © 2024 作者。由 Wolters Kluwer Health, Inc. 出版

The systemic inflammatory score (SIS), a new inflammatory marker based on a combination of the lymphocyte-to-monocyte ratio (LMR) and serum albumin concentration, has been reported to be a useful prognostic marker for several malignancies. The authors conducted this retrospective study on data from a cohort of esophageal cancer patients undergoing potentially curative resection to clarify the value of SIS as a prognostic marker for clinical outcome in this population.This retrospective cohort study included 32 patients who underwent thoracoscopic esophagectomy after neoadjuvant chemotherapy for esophageal cancer between January 2016 and December 2019. Blood samples were collected within one week prior to the initiation of preoperative chemotherapy. Three inflammatory and nutritional markers; SIS, the neutrophil-to-lymphocyte ratio (NLR), and prognostic nutrition index (PNI) were examined in this study. Disease-free survival was assessed using the Kaplan-Meier method, and univariable and multivariable Cox models were applied to evaluate the predictive value of SIS, NLR and PNI.NLR and PNI were not associated with recurrence, while SIS scores of 1 and 2 were significantly associated with recurrence. In multivariate analysis, SIS scores of 1 or 2 were found to be independently associated with recurrence, each with a hazard ratio of 1.98. In addition, when examining immunologic and nutritional factors and survival rates, there was no significant difference in the survival rate for NLR and PNI; for SIS, however, the survival rate was significantly worse in patients with SIS scores of 1 or 2.The authors demonstrated that a novel and easily obtained prognostic score, termed SIS, based on pre-treatment serum albumin and LMR, can serve as an independent prognostic factor in postoperative esophageal cancer patients. It could be incorporated into conventional clinical and pathological algorithms to enhance the prognostic accuracy in this population.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.