结直肠癌（CRC）是一种全球主要恶性肿瘤，持续对医学界构成挑战。尽管手术、化疗、放射、靶向和免疫治疗策略取得了进步，但耐药性和副作用等问题仍然存在。这篇综述阐明了铁死亡（一种新兴的非凋亡细胞死亡形式）和具有独特理化特性的氧化石墨烯 (GO) 在 CRC 治疗中的潜力。数据库检索包括 PubMed、Medline 和 Web of Science。搜索词集中于 CRC、石墨烯、GO、铁死亡以及治疗和药物输送的相关方面。文献检索的时间范围截至 2024 年 4 月。排除英语以外语言的研究。铁死亡因其在解决治疗耐药性方面的作用而得到认可，而治疗耐药性是有效 CRC 管理的一个显着障碍。这种形式的细胞死亡为增强现有治疗的有效性提供了一条有希望的途径。然而，了解其机制和对 CRC 的临床影响仍然是一个活跃的研究领域，其实际应用需要取得重大进展。同时，GO 作为一种多功能二维材料，在生物医学应用，特别是癌症治疗方面表现出了巨大的潜力。其高比表面积和独特的π电子域有利于化疗药物、靶基因和光敏剂的有效结合。这使得 GO 成为癌症诊断和治疗的有前途的候选者，特别是通过肿瘤光热和光动力疗法 (PDT)。尽管取得了这些进展，GO的临床应用仍面临挑战，包括体外细胞毒性和生物降解性下降，需要进一步研究。本综述重点介绍GO和铁死亡的特点，以及它们在肿瘤诊断和治疗中的应用，特别强调它们的应用CRC.2024 胃肠肿瘤学杂志的潜力。版权所有。

Colorectal cancer (CRC), a leading global malignancy, continues to challenge the medical community. Despite advancements in surgical, chemotherapeutic, radiation, targeted, and immunotherapeutic strategies, issues like resistance and side effects persist. This review illuminates the potential of ferroptosis, an emerging non-apoptotic cell death form, and graphene oxide (GO), with its distinctive physicochemical properties, in CRC therapy.The databases search included PubMed, Medline and Web of Science. Search terms focused on CRC, graphene, GO, ferroptosis, and related aspects in therapy and drug delivery. The time frame for literature retrieval was up to April 2024. Studies in languages other than English were excluded.Ferroptosis has been recognized for its role in addressing treatment resistance, a notable hurdle in effective CRC management. This form of cell death offers a promising avenue for enhancing the effectiveness of existing treatments. However, understanding its mechanisms and clinical implications in CRC remains an area of active research, with significant progress required for its practical application. Simultaneously, GO, a versatile two-dimensional material, has demonstrated substantial potential in biomedical applications, especially in cancer therapy. Its high specific surface area and unique π-electron domains facilitate the effective binding of chemotherapy drugs, target genes, and photosensitizers. This makes GO a promising candidate in cancer diagnosis and treatment, particularly through tumor photothermal and photodynamic therapy (PDT). Despite these advancements, GO's clinical application faces challenges, including in vitro cytotoxicity and decreased biodegradability, necessitating further research.This review focuses on the characteristics of GO and ferroptosis, as well as their applications in tumor diagnosis and treatment, with a particular emphasis on their potential in CRC.2024 Journal of Gastrointestinal Oncology. All rights reserved.