我们的目的是确定独立和补充自动乳腺超声 (ABUS) 在数字乳腺断层合成 (DBT) 机会性筛查环境中检测癌症的价值，并将这种联合筛查方法与单独使用 DBT 和 ABUS 的筛查方法在 39 岁以上患有 BI 的女性中进行比较-RADS B-D 密度类别。在这项前瞻性机会筛查研究中，纳入了 3466 名 39 岁或以上、具有 BI-RADS B-D 密度类别且平均年龄为 50 岁的女性。筛查方案包括 DBT 中外侧斜视图、2D 头尾视图和 ABUS（双侧乳房的三个投影）。 ABUS 的评估不考虑乳房 X 光检查结果。统计分析评估了 DBT、ABUS 和组合工作流程的诊断性能。筛查发现了二十九种癌症。 ABUS 和 DBT 表现出相同的癌症检出率 (CDR)，均为 7.5/1000，而 DBT  ABUS 显示为 8.4/1000，ABUS 贡献了额外的 CDR 0.9/1000。独立 ABUS 在检测浸润性癌症方面比 DBT 多出 12.5%。与 ABUS (88%) 和组合方法 (86%) 相比，DBT 显示出更高的准确性 (95%)。 DBT 和 ABUS 的敏感性相同 (84%)，其中 DBT  ABUS 的敏感性更高 (94%)。 DBT 的特异性优于 ABUS（95% vs. 88%）。与 ABUS (12.38%) 和 DBT (6.03%) 相比，DBT  ABUS 表现出更高的召回率 (14.89%) (p < .001)。与 DBT 相比，独立 ABUS 检测到更多侵袭性癌症，召回率更高。通过每千人中额外检测出一种癌症，组合方法显示出更高的 CDR。© 2024 作者。约翰·威利出版的《国际癌症杂志》

We aimed to determine the value of standalone and supplemental automated breast ultrasound (ABUS) in detecting cancers in an opportunistic screening setting with digital breast tomosynthesis (DBT) and compare this combined screening method to DBT and ABUS alone in women older than 39 years with BI-RADS B-D density categories. In this prospective opportunistic screening study, 3466 women aged 39 or older with BI-RADS B-D density categories and with a mean age of 50 were included. The screening protocol consisted of DBT mediolateral-oblique views, 2D craniocaudal views, and ABUS with three projections for both breasts. ABUS was evaluated blinded to mammography findings. Statistical analysis evaluated diagnostic performance for DBT, ABUS, and combined workflows. Twenty-nine cancers were screen-detected. ABUS and DBT exhibited the same cancer detection rates (CDR) at 7.5/1000 whereas DBT + ABUS showed 8.4/1000, with ABUS contributing an additional CDR of 0.9/1000. Standalone ABUS outperformed DBT in detecting 12.5% more invasive cancers. DBT displayed better accuracy (95%) compared to ABUS (88%) and combined approach (86%). Sensitivities for DBT and ABUS were the same (84%), with DBT + ABUS showing a higher rate (94%). DBT outperformed ABUS in specificity (95% vs. 88%). DBT + ABUS exhibited a higher recall rate (14.89%) compared to ABUS (12.38%) and DBT (6.03%) (p < .001). Standalone ABUS detected more invasive cancers compared to DBT, with a higher recall rate. The combined approach showed a higher CDR by detecting one additional cancer per thousand.© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.