IL17 信号传导促进胰腺癌的发展，但负责 IL17 促肿瘤功能的细胞区室尚未明确。在这篇文章中，Castro-Pando 及其同事证明，胰腺上皮中的 IL17/IL17 受体 A 信号传导对于胰腺癌的发生和建立免疫抑制至关重要，而其在免疫区室中的信号传导则是可有可无的。这项工作提供了关于 IL17 信号传导作用的重要机制见解，并确定了一个潜在的新免疫检查点作为胰腺癌的靶点。请参阅 Castro-Pando 等人的相关文章，第 17 页。 XXX (3).©2024 美国癌症研究协会。

IL17 signaling promotes pancreatic cancer development, yet the cell compartment responsible for the protumorigenic function of IL17 has not been defined. In this article, Castro-Pando and colleagues demonstrate that IL17/IL17 receptor A signaling in the pancreatic epithelium is critical for pancreatic cancer initiation and for establishing immunosuppression, whereas its signaling in the immune compartment is dispensable. This work provides an important mechanistic insight on the role of IL17 signaling and identifies a potential new immune checkpoint as a target in pancreatic cancer. See related article by Castro-Pando et al., p. XXX (3).©2024 American Association for Cancer Research.