与骨髓活检 (BMB) 相比，F-18 氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描 (PET/CT) 对非霍奇金淋巴瘤 (NHL) 患者的诊断效用仍有待证实。本研究旨在比较 BMB 和 PET/CT 对 NHL 患者骨髓浸润 (BMI) 的影响。检索了 PubMed、Embase 和 Cochrane 图书馆截至 2021 年 10 月发表的论文。结果为真阳性、阴性和假BMB 和 PET/CT 的阳性率和阴性率。计算总结的敏感性、特异性、阳性似然比 (PLR)、阴性似然比 (NLR) 和诊断比值比 (DOR)。纳入了 13 项研究，总共 2396 名患者。 BMB 和 PET/CT 的敏感性（相对比：0.749；95% CI：0.586-0.956；P=0.020）和 NLR（相对比：1.839；95% CI：1.106-3.058；P=0.019）之间存在显着差异。 ，但不适用于特异性 (P=0.819)、PLR (P=0.802) 和 DOR (P=0.150)。 PET/CT 的 BMB 受试者工作特征曲线下总面积为 0.692（SE：0.170）和 0.977（SE：0.021）。PET/CT 对于检测 NHL 患者的 BMI 具有更好的灵敏度和 NLR，而与 BMB 相比，在特异性、PLR 和 DOR 方面没有发现差异。

The diagnostic utility of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) compared to bone marrow biopsy (BMB) in patients with non-Hodgkin lymphoma (NHL) remained to be confirmed. This study aimed to compare BMB and PET/CT for bone marrow infiltration (BMI) in patients with NHL.PubMed, Embase, and the Cochrane library were searched for papers published up to October 2021. The outcomes were the true positive and negative and false positive and negative rates for BMB and PET/CT. The summarized sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratios (DOR) were calculated.Thirteen studies with a total of 2396 patients were included. Significant differences are observed between BMB and PET/CT for sensitivity (relative ratio: 0.749; 95% CI: 0.586-0.956; P=0.020) and NLR (relative ratio: 1.839; 95% CI: 1.106-3.058; P=0.019), but not for specificity (P=0.819), PLR (P=0.802), and DOR (P=0.150). The summary area under the receiver operating characteristic curves for BMB is 0.692 (SE: 0.170) and 0.977 (SE: 0.021) for PET/CT.PET/CT presents a better sensitivity and NLR for the detection of BMI in patients with NHL, whereas no differences are found regarding specificity, PLR, and DOR compared with BMB.