乳房切除术皮瓣坏死 (SFN) 在保留乳头的乳房切除术 (NSM) 后很常见，但对其生活质量 (QOL) 影响的研究有限。我们利用 BREAST-Q 患者报告的结果测量 (PROM) 调查检查了 NSM 联合/不联合 SFN 后患者报告的 QOL 和满意度。对 2018 年 4 月至 2021 年 7 月期间在我们机构接受 NSM 的患者进行了检查； BREAST-Q PROM 在术前、术后 6 个月和 1 年时进行。术后 2-3 周记录 SFN 的范围/严重程度；比较有/无 SFN 患者的生活质量和满意度。共纳入 333 名患者的 573 个 NSM，82 名患者的 135 个乳房出现 SFN（浅层 24%，部分厚度 56%，全层 16%）。与没有 SFN 的患者相比，患有 SFN 的患者在 6 个月时对乳房满意度 (p = 0.032) 和社会心理生活质量领域 (p = 0.009) 的评分显着较低，并且在 1 年时这两个领域的评分均恢复到基线。在“胸部健康”领域，所有患者的得分总体下降；然而，有或没有 SFN 的患者在任何时间点都没有显着差异。与未患有 SFN 的患者相比，患有 SFN 的患者在 6 个月和 1 岁时性幸福感评分有所下降，但这并未达到显着性（分别为 p = 0.13、p = 0.2）。接受 NSM 且出现 SFN 的患者报告性幸福感显着降低6 个月时的满意度和社会心理健康评分，1 年后恢复到基线。无论 SFN 如何，NSM 后胸部的身体健康都会显着下降。未来需要进行更大样本量和更长随访时间的研究，以确定 SFN 对长期 QOL 的影响。© 2024。外科肿瘤学会。

Mastectomy skin flap necrosis (SFN) is common following nipple-sparing mastectomy (NSM), but studies on its quality-of-life (QOL) impact are limited. We examined patient-reported QOL and satisfaction after NSM with/without SFN utilizing the BREAST-Q patient-reported outcome measure (PROM) survey.Patients undergoing NSM between April 2018 and July 2021 at our institution were examined; the BREAST-Q PROM was administered preoperatively, and at 6 months and 1 year postoperatively. SFN extent/severity was documented at 2-3 weeks postoperatively; QOL and satisfaction domains were compared between patients with/without SFN.A total of 573 NSMs in 333 patients were included, and 135 breasts in 82 patients developed SFN (24% superficial, 56% partial thickness, 16% full thickness). Patients with SFN reported significantly lower scores in the satisfaction with breasts (p = 0.032) and psychosocial QOL domains (p = 0.009) at 6 months versus those without SFN, with scores returning to baseline at 1 year in both domains. In the "physical well-being-of-the-chest" domain, there was an overall decline in scores among all patients; however, there were no significant differences at any time point between patients with or without SFN. Sexual well-being scores declined for patients with SFN compared with those without at 6 months and also at 1 year, but this did not reach significance (p = 0.13, p = 0.2, respectively).Patients undergoing NSM who developed SFN reported significantly lower satisfaction and psychosocial well-being scores at 6 months, which returned to baseline by 1 year. Physical well-being of the chest significantly declines after NSM regardless of SFN. Future studies with larger sample sizes and longer follow-up are needed to determine SFN's impact on long-term QOL.© 2024. Society of Surgical Oncology.