摄入的砷对人体泌尿道具有致癌性，但剂量-反应关系仍存在不确定性。为了评估砷摄入与泌尿系癌症之间的剂量反应关系，我们评估了台湾饮用水中的砷含量与膀胱癌、肾癌和前列腺癌死亡率之间的关联。我们利用1971-2000年台湾死亡登记数据，并以1976年世界标准人口为参考组计算年龄标准化死亡率（ASMR）。我们使用1974-1976年政府对饮用水中砷含量进行的井普查数据来评估暴露水平，将其分为三类：低于0.05 ppm、0.05-0.35 ppm和高于0.35 ppm 。使用多元线性回归模型和地理信息系统对数据进行分析。我们发现，在砷暴露水平为 0.05-0.35 ppm 时，所有或任何泌尿系癌症的 ASMR 均未增加，但在砷暴露水平 > 0.35 ppm 时，男性和女性膀胱癌、肾癌的 ASMR 增加相关，以及所有泌尿系癌症的总和。对于任一暴露类别，均未观察到与前列腺癌相关的 ASMR 增加。© 2024。作者获得 Springer Nature B.V. 的独家许可。

Ingested arsenic is carcinogenic to the human urinary tract, but uncertainties remain regarding the dose-response relationship. To assess dose-response relationships between arsenic ingestion and urinary cancers, we evaluated the associations between the arsenic level in drinking water and mortality of cancers of the bladder, kidney, and prostate in Taiwan. We utilized the 1971-2000 Taiwan death registry data and calculated the age-standardized mortality rates (ASMRs) using the 1976 world standard population as the reference group. We used the data from a 1974-1976 census survey of wells on the arsenic levels in drinking water conducted by the government to assess exposure levels, which had been divided into three categories: below 0.05 ppm, 0.05-0.35 ppm, and above 0.35 ppm. The data were analyzed using multiple linear regression models and geographical information system. We found no increase in ASMR for all, or any, of the urinary cancers at exposure levels of 0.05-0.35 ppm arsenic, but at exposure levels > 0.35 ppm arsenic was associated with increased ASMR in both males and females for bladder cancer, kidney cancer, and all urinary cancers combined. There was no increased ASMR associated with prostate cancer observed for either exposure category.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.