针对金丝桃素（Hyp）和替拉扎明（TPZ）临床应用中存在的问题，利用介孔二氧化硅纳米粒子（MSN）和海藻酸钠（SA）构建了具有协同抗肿瘤功能的纳米药物递送系统。该系统在肿瘤组织中表现出优异的稳定性、生理相容性和靶向药物释放性能。在体外和体内实验中，MSN释放的Hyp通过光动力疗法（PDT）杀死肿瘤细胞。肿瘤组织部位的缺氧程度加剧，使得TPZ能够充分发挥其抗肿瘤活性。我们的研究表明，纳米药物输送系统各成分之间的协同效应显着提高了 Hyp 和 TPZ 的抗肿瘤特性。版权所有 © 2024 Elsevier B.V. 保留所有权利。

To solve the problems existing in the clinical application of hypericin (Hyp) and tirapazamine (TPZ), a nano-drug delivery system with synergistic anti-tumor functions was constructed using mesoporous silica nanoparticles (MSN) and sodium alginate (SA). The system exhibited excellent stability, physiological compatibility and targeted drug release performance in tumor tissues. In the in vitro and in vivo experiments, Hyp released from MSN killed tumor cells through photodynamic therapy (PDT). The degree of hypoxia in the tumor tissue site was exacerbated, enabling TPZ to fully exert its anti-tumor activity. Our studies suggested that the synergistic effects between the components of the nano-drug delivery system significantly improve the anti-tumor properties of Hyp and TPZ.Copyright © 2024 Elsevier B.V. All rights reserved.