随着活性成分提取和表征技术的进步，源自大自然的天然物质的开发提出了重大挑战。 Hispolon 近年来因其广泛的生物活性而受到广泛关注。它是从桑黄、桑黄、桑黄、桑黄和桦褐孔菌等多种蘑菇中提取的酚类分子。为了全面概述 hispolon 的药理活性，本综述重点介绍了其抗癌、抗炎、抗氧化、抗菌和抗糖尿病活性。截至 2024 年 5 月，使用了多个科学研究数据库，包括 Google Scholar、Web of Science、PubMed、SciFinder、SpringerLink、Science Direct、Scopus 和 Wiley Online，收集了 hispolon 的数据。体外和体内研究表明， hispolon 通过改变多种信号通路（包括细胞凋亡、周期停滞、自噬以及抑制血管生成和转移）而表现出显着的抗癌特性。 Hispolon 的抗菌活性已被证明可对抗多种细菌、真菌和病毒病原体，凸显了其作为新型抗菌剂的潜在用途。此外，hispolon 通过抑制关键炎症介质（如诱导型 NO 合酶 (iNOS)、肿瘤坏死因子-α (TNF-α) 和环氧合酶-2 (COX-2)）和调节而表现出有效的抗炎活性。丝裂原激活蛋白激酶 (MAPK) 和核因子 kappa B (NF-κB) 信号通路。 hispolon 的抗氧化潜力归因于其中和活性氧 (ROS) 和增加抗氧化酶活性的能力，表明可能参与预防氧化应激相关疾病。 Hispolon 的抗糖尿病活性与醛糖还原酶和 α-葡萄糖苷酶的抑制有关。对 hispolon 的研究强调了其作为开发针对各种疾病（包括癌症、传染病、炎症性疾病和糖尿病）的新型治疗剂的有前途的支架的潜在用途。版权所有 © 2024 作者。由 Elsevier Masson SAS 出版。保留所有权利。

The development of natural substances derived from nature poses a significant challenge as technologies for the extraction and characterization of active principles advance. Hispolon has received a lot of attention in recent years, ascribable to its wide range of biological activities. It is a phenolic molecule that was extracted from several mushroom species such as Phellinus igniarius, Phellinus linteus, Phellinus lonicerinus, Phellinus merrillii, and Inonotus hispidus. To provide a comprehensive overview of the pharmacological activities of hispolon, this review highlights its anticancer, anti-inflammatory, antioxidant, antibacterial, and anti-diabetic activities. Several scientific research databases, including Google Scholar, Web of Science, PubMed, SciFinder, SpringerLink, Science Direct, Scopus, and, Wiley Online were used to gather the data on hispolon until May 2024. The in vitro and in vivo studies have revealed that hispolon exhibited significant anticancer properties through modifying several signaling pathways including cell apoptosis, cycle arrest, autophagy, and inhibition of angiogenesis and metastasis. Hispolon's antimicrobial activity was proven against many bacterial, fungal, and viral pathogens, highlighting its potential use as a novel antimicrobial agent. Additionally, hispolon displayed potent anti-inflammatory activity through the suppression of key inflammatory mediators, such as inducible NO synthase (iNOS), tumor necrosis factor-α (TNF-α), and cyclooxygenases-2 (COX-2), and the modulation of mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways. The antioxidant potential of hispolon was attributed to its capacity to neutralize reactive oxygen species (ROS) and to increase the activity of antioxidant enzymes, indicating a possible involvement in the prevention of oxidative stress-related illnesses. Hispolon's antidiabetic activity was associated with the inhibition of aldose reductase and α-glucosidase. Studies on hispolon emphasized its potential use as a promising scaffold for the development of novel therapeutic agents targeting various diseases, including cancer, infectious diseases, inflammatory disorders, and diabetes.Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.