尽管一些荟萃分析已经研究了双相情感障碍（BD）与其共病健康结果之间的关联，但这一证据尚未全面汇总。我们旨在系统地回顾基于多种身体结果的现有荟萃分析，并通过检查来验证证据水平现有证据的确定性。我们系统地检索了数据库，包括 PubMed/MEDLINE、Embase、Google Scholar 和 CINAHL，查找截至 2023 年 7 月发表的文章。我们纳入了队列、病例对照和/或横断面的荟萃分析研究调查 BD 患者的任何共病健康结果。我们使用 AMSTAR2 对纳入的荟萃分析进行了质量评估。研究结果的可信度分为证据类别和质量 (CE) 五个级别，包括令人信服、高度暗示、暗示、弱或不显着。我们分析了 12 项荟萃分析，其中包括 145 篇原创文章，涵盖 14 种独特的健康结果超过 6000 万参与者遍布 29 个国家和五大洲。在 14 种健康结果中，BD 与 8 种共病健康结果显着相关，包括痴呆（等效比值比 [eOR]，2.96 [95% 置信区间 {CI}，1.69-5.17]；CE=暗示性）、帕金森病（3.35 [ 1.72-6.53]；CE=建议性）、哮喘（1.86 [1.42-2.42]；CE=弱）、弓形体病（1.69 [1.21-2.37]；CE=弱）、高血压（1.28 [1.02-1.60]；CE=令人信服） ）、乳腺癌（1.33 [1.15-1.55]；CE=弱）、肥胖（1.64 [1.30-1.99]；CE=提示性）和 2 型糖尿病（1.98 [1.55-2.52]；CE=弱）。患有双相情感障碍的人容易出现许多共存的身体状况，尽管这些联系得到了各种证据水平的支持，并且需要进一步的研究。医生必须意识到 BD 患者的这些潜在合并症，并采取积极措施进行管理。版权所有 © 2024 Elsevier B.V。保留所有权利。

Although several meta-analyses have examined the association between bipolar disorder (BD) and its comorbid health outcomes, this evidence has not been comprehensively assembled.We aimed to systematically review existing meta-analyses based on multiple physical outcomes and validate the evidence level by examining the existing certainty of evidence.We systematically searched databases, including PubMed/MEDLINE, Embase, Google Scholar, and CINAHL, for articles published up to July 2023. We included meta-analyses of cohort, case-control, and/or cross-sectional studies investigating any comorbid health outcomes in patients with BD. We conducted quality assessments of the included meta-analysis using AMSTAR2. The credibility of findings was categorized into five levels of class and quality of evidence (CE), including convincing, highly suggestive, suggestive, weak, or not significant.We analyzed 12 meta-analyses, including 145 original articles, covering 14 unique health outcomes with over 60 million participants across 29 countries and five continents. Among 14 health outcomes, BD was significantly associated with eight comorbid health outcomes, including dementia (equivalent odds ratio [eOR], 2.96 [95 % confidence intervals {CI}, 1.69-5.17]; CE=suggestive), Parkinson's disease (3.35 [1.72-6.53]; CE=suggestive), asthma (1.86 [1.42-2.42]; CE=weak), toxoplasmosis (1.69 [1.21-2.37]; CE=weak), hypertension (1.28 [1.02-1.60]; CE=convincing), breast cancer (1.33 [1.15-1.55]; CE=weak), obesity (1.64 [1.30-1.99]; CE=suggestive), and type 2 diabetes mellitus (1.98 [1.55-2.52]; CE=weak).Individuals with BD are predisposed to numerous comorbid physical conditions, though these links are supported by various evidence levels and necessitate further studies. It is imperative that physicians be aware of these potential comorbidities in patients with BD and take proactive measures to manage them.Copyright © 2024 Elsevier B.V. All rights reserved.