乳腺癌 (BC) 的危险因素有多种，其中许多与身体成分、荷尔蒙状态和生育模式有关。然而，尚不清楚健康女性的危险因素是否与 BC 诊断时的特定乳房 X 线摄影特征相关。我们的目的是评估诊断前的身体成分与诊断 BC 图像中的乳房 X 线照相特征之间的潜在关联。前瞻性马尔默饮食和癌症研究包括 1991 年至 2014 年患有侵袭性 BC 的女性 (n = 1116)。记录基线时的 BC 危险因素（人体测量、绝经状态和产次）以及 BC 诊断的乳房 X 光检查数据（乳腺密度、乳房 X 光检查肿瘤外观和检测模式）。我们通过逻辑回归分析研究了人体测量指标和乳房 X 线摄影特征之间的关联，得出比值比 (OR) 和 95% 置信区间 (CI)。基线时的高体重指数 (BMI) (≥30) 与针状肿瘤之间存在关联外观（OR 1.370（95% CI：0.941-2.010）），主要见于临床检测出癌症的女性（OR 2.240（95% CI：1.280-3.940））和绝经后女性（OR 1.580（95% CI：1.030- 2.440））。此外，还发现高 BMI (≥ 30) 与高乳腺密度 (OR 0.270 (95% CI: 0.166-0.438)) 之间呈负相关。这项研究证明了肥胖与乳房 X 光检查中的针状肿块之间存在关联，尤其是在患有以下疾病的女性中：临床检测到的癌症和绝经后妇女。这些发现提供了关于健康女性危险因素与随后 BC 相关乳房 X 光检查特征之间关系的见解。随着 BC 发病率和肥胖女性数量的增加，强调体重不健康女性的乳房 X 光检查结果非常重要。肥胖女性BC 可能会出现某些乳房 X 光检查特征。针状肿块在肥胖女性中更常见，尤其是绝经后女性，以及临床检测到 BC 的女性。关于肥胖与相关乳房 X 光检查特征之间关系的见解将有助于乳房 X 光检查的解释。© 2024。作者。

There are several breast cancer (BC) risk factors-many related to body composition, hormonal status, and fertility patterns. However, it is not known if risk factors in healthy women are associated with specific mammographic features at the time of BC diagnosis. Our aim was to assess the potential association between pre-diagnostic body composition and mammographic features in the diagnostic BC image.The prospective Malmö Diet and Cancer Study includes women with invasive BC from 1991 to 2014 (n = 1116). BC risk factors at baseline were registered (anthropometric measures, menopausal status, and parity) along with mammography data from BC diagnosis (breast density, mammographic tumor appearance, and mode of detection). We investigated associations between anthropometric measures and mammographic features via logistic regression analyses, yielding odds ratios (OR) with 95% confidence intervals (CI).There was an association between high body mass index (BMI) (≥ 30) at baseline and spiculated tumor appearance (OR 1.370 (95% CI: 0.941-2.010)), primarily in women with clinically detected cancers (OR 2.240 (95% CI: 1.280-3.940)), and in postmenopausal women (OR 1.580 (95% CI: 1.030-2.440)). Furthermore, an inverse association between high BMI (≥ 30) and high breast density (OR 0.270 (95% CI: 0.166-0.438)) was found.This study demonstrated an association between obesity and a spiculated mass on mammography-especially in women with clinically detected cancers and in postmenopausal women. These findings offer insights on the relationship between risk factors in healthy women and related mammographic features in subsequent BC.With increasing numbers of both BC incidence and women with obesity, it is important to highlight mammographic findings in women with an unhealthy weight.Women with obesity and BC may present with certain mammographic features. Spiculated masses were more common in women with obesity, especially postmenopausal women, and those with clinically detected BCs. Insights on the relationship between obesity and related mammographic features will aid mammographic interpretation.© 2024. The Author(s).