研究动态
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紫金牛属:植物化学、药理学和毒理学综述。

The genus Myrsine: A review of phytochemistry, pharmacology, and toxicology.

发表日期:2024 Jul 09
作者: Nguyen Thi Thoa, Ninh The Son
来源: Parasites & Vectors

摘要:

紫金牛(报春花科)含有开花物种。从药理学上讲,该属的植物属于诱导感染和炎症治疗的药用植物。目前还没有科学出版物对植物化学和药理活性进行综述。植物化学物质、色谱信息、精油和药理评论的汇编和分类是最终目的。从各种来源收集了有关香豆属植物化学和药理研究的参考文献,例如从 20 世纪 90 年代至今的 Google Scholar、PubMed 和 Web of Science。主关键词“Myrsine”单独使用或与其他关键词结合使用来检索参考文献。通过Myrsine提取物的色谱分析,纯化了134种化合物。类黄酮、单酚、皂苷、醌、巨豆花和木酚素是主要的植物化学物质类别。香豆素挥发性化合物有单萜类、倍半萜类和脂肪族化合物。香豆素成分建立了广泛的药理活性,例如细胞毒性、抗氧化、抗菌、抗寄生虫、酪氨酸抑制和保肝,尤其是抗炎。新型类黄酮 myrsininones A-B 比标准三氯生对华氏葡萄球菌、变形链球菌、血链球菌和内氏放线菌的抵抗力更好。 M. seguinii 地上部分乙醇提取物通过 Src/Syk/NF-κB(肉瘤激酶/脾酪氨酸激酶/核因子-κ B)和 IRAK-1/AP-1(白细胞介素)抑制 LPS(脂多糖)刺激的炎症 Raw 264.7 细胞-1 受体相关激酶-1/激活蛋白-1) 信号传导抑制。一般来说,香豆素植物提取物没有毒性。香豆素成分是良好的抗菌、抗氧化和抗炎剂。然而,大多数早期研究都集中在非洲木犀的药理学分析上。因此,需要对其余物种进行全面的研究。版权所有 © 2023。由 Elsevier B.V. 出版。
Myrsine (the family Primulaceae) contains flowering species. Pharmacologically, the plants of this genus belong to a list of medicinal plants that induce infectious and inflammatory treatments. There are no scientific publications that review phytochemistry and pharmacological activities.The compilation and classification of phytochemicals, chromatographic information, essential oils, and pharmacological reviews are the ultimate aim.References on phytochemical and pharmacological investigations of Myrsine species were collected from various sources, such as Google Scholar, PubMed, and Web of Science from the 1990s to present. The main keyword "Myrsine" was used alone or in combination with others to search for references.Chromatographic procedure of Myrsine extracts led to the purification of 134 compounds. Flavonoids, mono-phenols, saponins, quinones, megastigmanes, and lignans were the main phytochemical classes. Myrsine Volatile compounds are monoterpenoids, sesquiterpenoids, and aliphatic compounds. Myrsine constituents established a widespread panel of pharmacological activities, such as cytotoxicity, antioxidant, antimicrobial, anti-parasite, tyrosine inhibition, and hepatoprotection, especially anti-inflammation. Novel flavonoids myrsininones A-B are better than the standard triclosan against bacteria Staphylococcus warneri, S. mutan, S. sanguis, and Actinomyces naeslundii. M. seguinii aerial part ethanolic extract inhibited LPS (lipopolysaccharide)-stimulated inflammatory Raw 264.7 cells via Src/Syk/NF-κB (sarcoma kinase/spleen tyrosine kinase/ nuclear factor-kappa B) and IRAK-1/AP-1 (interleukin-1 receptor-associated kinase-1/activating protein-1) signaling inhibition. Generally, Myrsine plant extracts showed no toxicity.Myrsine constituents are good antimicrobial, antioxidative, and anti-inflammatory agents. However, the majority of earlier research focuses on the pharmacological analyses of M. africana. Thus, comprehensive findings for the remaining species are needed.Copyright © 2023. Published by Elsevier B.V.