非酒精性脂肪肝 (NAFLD) 在年轻人中的患病率不断上升，特别是在工作年龄（15-64 岁）的人群中，已成为一个公共健康问题。在较年轻的年龄被诊断意味着由于可能发展为肝硬化或肝细胞癌等疾病，因此在以后的生活中累积伤残调整生命年（DALY）的可能性更大。本研究旨在分析三十年来全球、区域和国家范围内的 NAFLD 患病率趋势，重点关注年龄、时期和出生队列关联。 1990 年至 2019 年：基于 2019 年全球疾病负担研究估计的年龄期队列分析，以及从 2019 年全球疾病、伤害和风险因素研究中提取的工作年龄人口 NAFLD 患病率 95% 的不确定区间 (UI)使用年龄-时期-队列模型来估计 1990 年至 2019 年每个年龄组内的患病率（局部漂移，每年％）、根据时期偏差（年龄效应）调整的拟合纵向年龄特定率以及时期/队列相对值。从 1990 年（每 10 万人 14,477.6 人）到 2019 年（每 10 万人 19,837.6 人），NAFLD 的全球年龄标准化患病率 (ASPR) 显着增加。在西太平洋地区，2019年有42,903.8例NAFLD病例，比1990年增加了54.15%。过去三十年来，该地区的ASPR也显着增加。在国家层面，帕劳的 ASPR 最高，而文莱达鲁萨兰国的 ASPR 最低。年龄-时期-队列分析显示，与全球不同，西太平洋地区的 NAFLD 风险在 60-64 岁之后下降。与 1980-1989 年相比，在随后的出生队列中，发病率和 DALY 风险有所下降，但患病率有所上升。未来的预测表明，NAFLD 负担呈上升趋势，尤其是在女性和中国等中等 (SDI) 地区。非酒精性脂肪肝造成巨大的健康负担，这种负担在全球和亚太地区持续增长。我们的工作强调工作年龄成年人作为高危群体，并呼吁人们关注西太平洋国家的社会经济梯度。未来的预测表明，NAFLD 预防是当务之急。© 2024。作者。

The growing prevalence of non-alcoholic fatty liver disease (NAFLD) in younger populations, particularly those of working age (15-64 years), has become a public health concern. Being diagnosed at a younger age implies a greater likelihood of accruing disability-adjusted life years (DALYs) later in life due to potential progression to conditions such as cirrhosis or hepatocellular carcinoma. This study aims to analyze NAFLD prevalence trends over three decades globally, regionally, and nationally, with a focus on age, period, and birth cohort associations.Global, regional, and country time trends in the prevalence of NAFLD among working-age people from 1990 to 2019: Age-period-cohort analysis based on Global Burden of Disease Study 2019 estimates and 95% uncertainty interval (UI) of NAFLD prevalence in the working age population was extracted from the Global Burden of Diseases, Injuries and Risk Factors Study 2019. Age-period-cohort models were used to estimate the prevalence within each age group from 1990 to 2019 (local drift, % per year), fitted longitudinal age-specific rates adjusted for period bias (age effect), and period/cohort relative risk (period/cohort effect).The global age-standardized prevalence (ASPR) of NAFLD increased significantly from 1990 (14,477.6 per 100 000) to 2019 (19,837.6 per 100 000). In the Western Pacific, there were 42,903.8 NAFLD cases in 2019, 54.15% higher than in 1990. The ASPR also increased significantly in the region over the past three decades. At the national level, Palau had the highest ASPR while Brunei Darussalam had the lowest. Age-period-cohort analysis showed that in the Western Pacific, unlike globally, the risk of NAFLD declined after age 60-64 years. Relative to 1980-1989, incidence and DALY risks decreased but prevalence increased in subsequent birth cohorts. Future predictions indicate an upward trend in NAFLD burden, especially among women and medium (SDI) regions like China.Non-alcoholic fatty liver disease imparts an immense health burden that continues to grow globally and in the Asia Pacific region. Our work highlights working age adults as an at-risk group and calls attention to socioeconomic gradients within Western Pacific countries. Upward future projections demonstrate that NAFLD prevention is an urgent priority.© 2024. The Author(s).