本研究比较了 I 期非小细胞肺癌 (NSCLC)≤ 2 cm 患者热消融与楔形切除后的生存结果。数据来自美国 (US) 国家癌症研究所流行病学监测和最终结果 (SEER) 数据库对2004年至2019年的情况进行回顾性分析。包括接受热消融或楔形切除术的 I 期 NSCLC 且病变≤≤2 cm 的患者。接受化疗或放疗的患者被排除在外。应用倾向评分匹配 (PSM) 来平衡接受两种手术的患者之间的基线特征。进行单变量和 Cox 回归分析以确定研究变量、总生存期 (OS) 和癌症特异性生存期 (CSS) 之间的关联）。 PSM 后，仍有 328 名患者进行分析。多变量 Cox 回归分析显示，与楔形切除相比，热消融与较高的 OS 不良风险显着相关（调整后 HR [aHR]：1.34，95% CI：1.09-1.63，p = 0.004），但与 CSS 无关（aHR： 1.28，95% CI：0.96-1.71，p = 0.094）。在分层分析中，无论组织学和分级如何，两种手术之间的 OS 和 CSS 均未观察到显着差异。在肿瘤大小为 1 至 2 cm 的患者中，与楔形切除相比，热消融与较高的 OS 不良风险显着相关（aHR：1.35，95% CI：1.10-1.66，p = 0.004）。相比之下，对于肿瘤大小≤1cm的患者，热消融和楔形切除的OS和CSS没有显着差异。对于肿瘤大小≤1cm的I期NSCLC患者，热消融与楔形切除具有相似的OS和CSS .© 2024。作者。

This study compared the survival outcomes after thermal ablation versus wedge resection in patients with stage I non-small cell lung cancer (NSCLC) ≤ 2 cm.Data from the United States (US) National Cancer Institute Surveillance Epidemiology and End Results (SEER) database from 2004 to 2019 were retrospectively analyzed. Patients with stage I NSCLC and lesions ≤ 2 cm who received thermal ablation or wedge resection were included. Patients who received chemotherapy or radiotherapy were excluded. Propensity-score matching (PSM) was applied to balance the baseline characteristics between patients who underwent the two procedures.Univariate and Cox regression analyses were performed to determine the associations between study variables, overall survival (OS), and cancer-specific survival (CSS). After PSM, 328 patients remained for analysis. Multivariable Cox regression analysis revealed, compared to wedge resection, thermal ablation was significantly associated with a greater risk of poor OS (adjusted HR [aHR]: 1.34, 95% CI: 1.09-1.63, p = 0.004) but not CSS (aHR: 1.28, 95% CI: 0.96-1.71, p = 0.094). In stratified analyses, no significant differences were observed with respect to OS and CSS between the two procedures regardless of histology and grade. In patients with tumor size 1 to 2 cm, compared to wedge resection, thermal ablation was significantly associated with a higher risk of poor OS (aHR: 1.35, 95% CI: 1.10-1.66, p = 0.004). In contrast, no significant difference was found on OS and CSS between thermal ablation and wedge resection among those with tumor size < 1 cm.In patients with stage I NSCLC and tumor size < 1 cm, thermal ablation has similar OS and CSS with wedge resection.© 2024. The Author(s).