外泌体：生物学功能、诊断和靶向治疗应用以及临床试验的综述。
Exosomes: a review of biologic function, diagnostic and targeted therapy applications, and clinical trials.
发表日期：2024 Jul 11
作者：
Yi-Fan Chen, Frank Luh, Yuan-Soon Ho, Yun Yen
来源：
JOURNAL OF BIOMEDICAL SCIENCE
摘要：
外泌体是所有细胞产生的细胞外囊泡，它们携带核酸、蛋白质、脂质和代谢物。它们介导细胞间的物质交换，从而影响受体细胞的生物学特性和活动。在这篇综述中，我们简要讨论了外泌体的组成和外泌体的分离。我们还回顾了外泌体在癌症生物学中的临床应用以及外泌体介导的靶向药物递送系统的策略。最后，讨论了外泌体在癌症治疗中在实践和文献中的应用。© 2024。作者。
Exosomes are extracellular vesicles generated by all cells and they carry nucleic acids, proteins, lipids, and metabolites. They mediate the exchange of substances between cells,thereby affecting biological properties and activities of recipient cells. In this review, we briefly discuss the composition of exocomes and exosome isolation. We also review the clinical applications of exosomes in cancer biology as well as strategies in exosome-mediated targeted drug delivery systems. Finally, the application of exosomes in the context of cancer therapeutics both in practice and literature are discussed.© 2024. The Author(s).