铁死亡是一种新兴的程序性细胞死亡类型，由铁依赖性和过度 ROS 介导的脂质过氧化引发，最终导致质膜破裂和细胞死亡。许多经典信号通路和生物过程都与铁死亡有关。此外，由于高活性氧负荷和独特的代谢特征（包括铁需求），癌细胞更容易出现铁死亡。最近的研究表明，铁死亡在肿瘤尤其是肝癌的进展中起着至关重要的作用。具体来说，诱导铁死亡不仅可以抑制肝癌细胞的生长，从而逆转肿瘤发生，而且可以提高免疫治疗的疗效，增强抗肿瘤免疫反应。因此，引发铁死亡已成为癌症治疗的新治疗策略。在这篇综述中，我们根据铁死亡的潜在机制和在 HCC 中的作用总结了铁死亡的特征，并提供了可能的治疗应用。© 作者。

Ferroptosis, an emerging type of programmed cell death, is initiated by iron-dependent and excessive ROS-mediated lipid peroxidation, which eventually leads to plasma membrane rupture and cell death. Many canonical signalling pathways and biological processes are involved in ferroptosis. Furthermore, cancer cells are more susceptible to ferroptosis due to the high load of ROS and unique metabolic characteristics, including iron requirements. Recent investigations have revealed that ferroptosis plays a crucial role in the progression of tumours, especially HCC. Specifically, the induction of ferroptosis can not only inhibit the growth of hepatoma cells, thereby reversing tumorigenesis, but also improves the efficacy of immunotherapy and enhances the antitumour immune response. Therefore, triggering ferroptosis has become a new therapeutic strategy for cancer therapy. In this review, we summarize the characteristics of ferroptosis based on its underlying mechanism and role in HCC and provide possible therapeutic applications.© The author(s).