miRNA 是小型、保守的单链非编码 RNA，通常由外泌体转运以发挥其功能作用。外泌体 miRNA 在多种疾病中的治疗潜力已得到探索，包括乳腺癌、胰腺癌、胆管癌、皮肤病、阿尔茨海默病、中风和神经胶质瘤。细胞炎症、凋亡、坏死、免疫功能障碍、氧化应激等病理生理过程与miRNA密切相关。组织缺血、缺氧、病原体感染和内毒素暴露等内部和外部因素可以触发这些反应，并且与 miRNA 相关。百草枯诱导的纤维化是一个旷日持久的过程，可能不会在受伤后立即显现出来，而是在身体恢复过程中发生，这为潜在的 miRNA 干预治疗提供了见解。这些发现可能应用于百草枯诱导的肺纤维化的进一步药物研究和临床治疗，以及参与肺纤维化研究的临床医生可能会非常感兴趣。通过文献综述，我们确定了 miR-15a-5p 和 miR-152-3p 之间的关联及其参与 Wnt 信号通路。这使我们能够推断出百草枯诱导的肺纤维化中涉及的调控相互作用的分子机制。miR-15a-5p和miR-152-3p在身体修复过程中发挥作用，肺纤维化可以被认为是机体修复反应的一种形式。身体。尽管纤维化修复的最初目的是恢复正常的身体功能，但与外部皮肤创伤后形成疤痕不同，过度的组织纤维化会对身体产生显着的不利影响。调节Wnt/β-catenin信号通路有利于减轻多种疾病中的组织纤维化。在本研究中，我们描绘了miR-15a-5p和miR-152-3p与Wnt/β-catenin信号通路之间的关联，提出了解决百草枯引起的肺纤维化的新概念。© 2024 Liu 和guan。

miRNAs are small, conserved, single-stranded non-coding RNA that are typically transported by exosomes for their functional roles. The therapeutic potential of exosomal miRNAs has been explored in various diseases including breast cancer, pancreatic cancer, cholangiocarcinoma, skin diseases, Alzheimer's disease, stroke, and glioma. Pathophysiological processes such as cellular inflammation, apoptosis, necrosis, immune dysfunction, and oxidative stress are closely associated with miRNAs. Internal and external factors such as tissue ischemia, hypoxia, pathogen infection, and endotoxin exposure can trigger these reactions and are linked to miRNAs. Paraquat-induced fibrosis is a protracted process that may not manifest immediately after injury but develops during bodily recovery, providing insights into potential miRNA intervention treatments.These findings could potentially be applied for further pharmaceutical research and clinical therapy of paraquat-induced pulmonary fibrosis, and are likely to be of great interest to clinicians involved in lung fibrosis research.Through a literature review, we identified an association between miR-15a-5p and miR-152-3p and their involvement in the Wnt signaling pathway. This allowed us to deduce the molecular mechanisms underlying regulatory interactions involved in paraquat-induced lung fibrosis.miR-15a-5p and miR-152-3p play roles in body repair processes, and pulmonary fibrosis can be considered a form of reparative response by the body. Although the initial purpose of fibrotic repair is to restore normal body function, excessive tissue fibrosis, unlike scar formation following external skin trauma, can significantly and adversely affect the body. Modulating the Wnt/β-catenin signaling pathway is beneficial in alleviating tissue fibrosis in various diseases.In this study, we delineate the association between miR-15a-5p and miR-152-3p and the Wnt/β-catenin signaling pathway, presenting a novel concept for addressing paraquat-induced pulmonary fibrosis.© 2024 Liu and Guan.