调节细胞死亡是细胞死亡的一种调节形式，已在多细胞生物中得到广泛研究。它在正常和病理条件下维持机体稳态中发挥着关键作用。尽管各种受调节的细胞死亡模式的改变是肿瘤发生的标志特征，但它们对癌细胞可能产生不同的影响。因此，人们越来越关注使用小分子化合物来靶向这些机制进行治疗，并且在各种人类癌症中观察到了实质性进展。本综述重点总结与细胞凋亡和自噬依赖性细胞死亡相关的关键信号通路。此外，它还探索了与癌症背景下其他受调节细胞死亡模式相关的关键途径。此次讨论深入探讨了目前对这些过程的理解及其对癌症治疗的影响，旨在阐明对抗治疗耐药性和增强整体癌症治疗的新策略。

Regulated cell death, a regulatory form of cell demise, has been extensively studied in multicellular organisms. It plays a pivotal role in maintaining organismal homeostasis under normal and pathological conditions. Although alterations in various regulated cell death modes are hallmark features of tumorigenesis, they can have divergent effects on cancer cells. Consequently, there is a growing interest in targeting these mechanisms using small-molecule compounds for therapeutic purposes, with substantial progress observed across various human cancers. This review focuses on summarizing key signaling pathways associated with apoptotic and autophagy-dependent cell death. Additionally, it explores crucial pathways related to other regulated cell death modes in the context of cancer. The discussion delves into the current understanding of these processes and their implications in cancer treatment, aiming to illuminate novel strategies to combat therapy resistance and enhance overall cancer therapy.