马乔林溃疡 (MU) 是一种罕见的侵袭性皮肤肿瘤。有大量病例报告，但缺乏大型长期研究，需要进一步探索其治疗方法。本研究旨在总结分析MU的特点、治疗方法及预后。我们回顾性分析了烧伤中心2013年1月至2023年1月收治的126例MU患者的临床资料。对人口学数据、临床特征、治疗和预后进行统计分析。在纳入的126例患者中，104例获得了0.1-10.2年的随访。原发伤害最常见的原因是火焰烧伤（50.8%）。病变多见于下肢（47.6%）。主要的组织病理学类型是鳞状细胞癌（92.8%）。 126例患者中，35例（27.8%）出现骨侵犯，37例（29.4%）出现淋巴结肿大，9例（7.1%）出现淋巴结转移。广泛局部切除（83.3%）是最常见的手术方式；缺损采用植皮（41.9%）、游离皮瓣（37.1%）和局部皮瓣（21.0%）修复。多因素分析显示骨侵犯和淋巴结受累是术后复发的危险因素。生存分析显示，年龄、潜伏期、病理类型和复发是生存的重要危险因素。根除肿瘤需要广泛的局部切除，术后1年内应更加频繁地随访患者。由于 MU 是可以预防的，因此必须在发生致命转移之前进行快速诊断并避免延迟治疗。© 作者 2024。由牛津大学出版社代表美国烧伤协会出版。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

Marjolin's ulcer (MU) is a rare, aggressive skin tumor. There are numerous case reports but large long-term studies are lacking, necessitating further exploration of its treatment. This study aimed to summarize and analyze the characteristics, treatment methods, and prognosis of MU.We retrospectively analyzed the clinical data of 126 patients with MU, treated between January 2013 and January 2023 at the burn center. Demographic data, clinical characteristics, treatment, and prognosis were statistically analyzed.Of the 126 included patients, 104 were followed up for 0.1-10.2 years. The most common cause of the primary injury was flame burn (50.8%). Lesions were commonly observed on the lower limbs (47.6%). The predominant histopathological type was squamous cell carcinoma (92.8%). Among the 126 patients, 35 (27.8%) presented with bone invasion, 37 (29.4%) presented with enlarged lymph nodes, and 9 (7.1%) had lymph node metastasis. Extensive local excision (83.3%) was the most common surgical procedure; the defect was repaired using skin grafting (41.9%), free flaps (37.1%), and local flaps (21.0%). Multivariate analysis revealed that bone invasion and lymph node involvement were risk factors for postoperative recurrence. Survival analysis showed that age, latency period, pathological type, and recurrence were significant risk factors for survival.Extensive local resection is necessary to eradicate tumors, and patient follow-up should be more frequent within 1 year postoperatively. As MU is preventable, it is essential to reach a quick diagnosis and avoid delayed management before the occurrence of deadly metastases.© The Author(s) 2024. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.