法布里病 (FD) 与炎症、蛋白尿和慢性肾脏病有关。肿瘤坏死因子样弱凋亡诱导剂（TWEAK）在糖尿病肾病和狼疮肾炎的炎症中发挥重要作用。由于各种肾脏疾病中血清 TWEAK (sTWEAK)、炎症和颈动脉内膜中层厚度 (CIMT) 之间存在密切关系，因此我们旨在通过交叉研究确定有或无蛋白尿受试者中 sTWEAK 水平与 CIMT 之间的关系。截面研究涉及 15 名 FD 患者（7 名女性，8 名男性）和 7 名健康对照者（4 名女性，3 名男性）。 FD患者之间的年龄、性别、估计肾小球滤过率和生化参数（血清葡萄糖、白蛋白、肌酐、尿酸、C反应蛋白（CRP）、低密度脂蛋白和高密度脂蛋白）没有差异和健康的控制。健康对照者和FD患者的点尿蛋白肌酐比值分别为90 mg/g和185 mg/g（P = 0.022）。 FD 患者的 STWEAK 水平高于健康对照者 (P = 0.007)。 FD患者和健康对照的CIMT分别为0.55±0.14mm和0.42±0.04mm(P=0.007)。 STWEAK 与 CRP 和 CIMT 呈正相关，与蛋白尿呈负相关（分别为 P = 0.005、P = 0.013 和 P = 0.018）。在多变量分析中，只有 sTWEAK 是 CIMT 增加的自变量。我们证明 FD 患者的 sTWEAK 和 CIMT 增加。 STWEAK 可能在 FD 亚临床动脉粥样硬化的发病机制中发挥作用。版权所有 © 2023 版权所有：© 2023 沙特肾脏疾病和移植杂志。

Fabry disease (FD) is associated with inflammation, proteinuria, and chronic kidney disease. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) plays an important role in inflammation in diabetic nephropathy and lupus nephritis. Since there is a close relationship linking serum TWEAK (sTWEAK), inflammation, and carotid intima-media thickness (CIMT) in various kidney diseases, we aimed to determine the relationship between sTWEAK levels and CIMT in subjects with and without proteinuria in a cross-sectional study involving 15 FD patients (seven females, eight males) and seven healthy controls (four females, three males). There were no differences in age, sex, estimated glomerular filtration rate, and biochemical parameters (serum glucose, albumin, creatinine, uric acid, C-reactive protein (CRP), low-density lipoprotein, and high-density lipoprotein) between FD patients and healthy controls. The spot urine protein-creatinine ratios of healthy controls and FD patients were 90 mg/g and 185 mg/g, respectively (P = 0.022). STWEAK levels were higher in FD patients than in healthy controls (P = 0.007). The CIMT of FD patients and healthy controls was 0.55 ± 0.14 mm and 0.42 ± 0.04 mm, respectively (P = 0.007). STWEAK was positively correlated with CRP and CIMT, and negatively with proteinuria (P = 0.005, P = 0.013, and P = 0.018, respectively). In the multivariate analysis, only sTWEAK was an independent variable of increased CIMT. We demonstrated that sTWEAK and CIMT were increased in FD patients. STWEAK might have a role in the pathogenesis of subclinical atherosclerosis in FD.Copyright © 2023 Copyright: © 2023 Saudi Journal of Kidney Diseases and Transplantation.