抗酒石酸酸性磷酸酶 5b (TRACP5b) 的血清水平是骨吸收的极好血清标志物。据报道，骨巨细胞瘤 (GCTB) 患者的 TRACP5b 水平升高。本研究调查了 TRACP5b 是否可以作为诊断血清标志物，并可用于检测 GCTB 术后疾病进展。队列 1：我们从数据库中提取了 120 名进行 TRACP5b 测量的患者的数据：49 名 GCTB 患者和 71 名非 GCTB 患者。我们比较了 GCTB 组和非 GCTB 组之间的血清 TRACP5b 值。第 2 组包括 47 名 GCTB 患者，他们进行了超过 6 个月的随访并具有多个 TRACP5b 值。对于局部复发的患者，通过比较进展前的TRACP5b值(a)和进展时的值(b)来计算TRACP5b变化率：变化率 = [(b)-(a)]/(a) 。在非进展组中，根据两个连续的TRACP5b值(c)和(d)计算变化率：变化率 =[(c)-(d)]/(c)。我们比较了进展组和非进展组之间的 TRACP5b 变化率。队列 1：GCTB 组的平均 TRACP5b 值 (1756 ± 2021 mU/dL) 显着高于非 GCTB 组 (415± 219 mU/dL)（ p < 0.0001)。第2组：进展组的平均TRACP5b变化率显着高于非进展组（分别为8.53±8.52和0.24±0.27；p<0.0001）。TRACP5b是GCTB的有用诊断标志物。血清 TRACP5b 值的变化率是预测 GCTB 局部复发的高度敏感标志物。© 2024。作者获得日本临床肿瘤学会独家许可。

Serum level of tartrate-resistant acid phosphatase 5b (TRACP5b) is an excellent serum marker of bone resorption. In patients with giant cell tumor of bone (GCTB), TRACP5b levels are reportedly elevated. This study investigated whether TRACP5b could be a diagnostic serum marker and be useful for detecting postoperative disease progression for GCTB.Cohort 1: We abstracted data from 120 patients with TRACP5b measurements from our database: 49 patients with GCTB and 71 patients non-GCTB. We compared serum TRACP5b values between the GCTB and non-GCTB groups. Cohort 2 included 47 patients with GCTB who had more than 6 months of follow-up and multiple TRACP5b values. For patients with local recurrence, TRACP5b change rate was calculated by comparing the TRACP5b value just before progression (a) with the value at the time of progression (b): Change rate = [(b)-(a)]/(a). In the non-progression group, the change rate was calculated from the two consecutive TRACP5b values, (c) and (d): Change rate =[(c)-(d)]/(c). We compared TRACP5b change rates between the progression and non-progression groups.Cohort 1: The GCTB group had a significantly higher mean TRACP5b value (1756 ± 2021 mU/dL) than the non-GCTB group (415 ± 219 mU/dL) (p < 0.0001). Cohort 2: The mean TRACP5b change rate of the progression group was significantly higher than the non-progression group (8.53 ± 8.52 and 0.24 ± 0.27, respectively; p < 0.0001).TRACP5b is a useful diagnostic marker in GCTB. The rate of change in serum TRACP5b values is a highly sensitive marker for predicting local recurrence in GCTB.© 2024. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.