干细胞衍生的细胞外囊泡（SC-EV）已成为伤口修复的有前途的治疗剂，它重现了亲本细胞的生物学效应，同时减轻了免疫原性和致瘤风险。这些 EV 协调伤口愈合过程，特别是通过调节血管生成（组织血运重建和再生中的关键事件）。这项研究全面概述了伤口微环境中各种干细胞来源的 EV 的促血管生成能力的多方面机制。通过阐明控制其血管生成能力的分子复杂性，我们的目标是揭示其加速伤口愈合的巨大潜力背后的机制。此外，还强调了增强 SC-EV 的血管生成作用的方法、当前的局限性和未来的前景，强调了这一快速发展的领域在彻底改变伤口愈合策略方面的巨大潜力。© 2024。作者获得独家许可Springer Science Business Media, LLC，隶属于 Springer Nature。

Stem cells-derived extracellular vesicles (SC-EVs) have emerged as promising therapeutic agents for wound repair, recapitulating the biological effects of parent cells while mitigating immunogenic and tumorigenic risks. These EVs orchestrate wound healing processes, notably through modulating angiogenesis-a critical event in tissue revascularization and regeneration. This study provides a comprehensive overview of the multifaceted mechanisms underpinning the pro-angiogenic capacity of EVs from various stem cell sources within the wound microenvironment. By elucidating the molecular intricacies governing their angiogenic prowess, we aim to unravel the mechanistic repertoire underlying their remarkable potential to accelerate wound healing. Additionally, methods to enhance the angiogenic effects of SC-EVs, current limitations, and future perspectives are highlighted, emphasizing the significant potential of this rapidly advancing field in revolutionizing wound healing strategies.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.